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The Parkinson's, Genes and Environment (PAGE) Study

50 Years
80 Years
Open (Enrolling)
Parkinson's Disease (PD)

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Trial Information

The Parkinson's, Genes and Environment (PAGE) Study

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, affecting
more than 1 million elderly Americans. The causes of PD are largely unknown, but may include
both genetic and environmental factors. We thus propose a large study to investigate the
roles of diet, lifestyle, genes and their potential interactions in PD etiology, using the
NIH-AARP Diet and Health Study. The AARP cohort was established by investigators at NCI and
recruited over half a million participants in 1995 and had prospectively collected detailed
information on diet and lifestyle. At baseline, participants were 50 years or older and
included 40% women. After more than 8 years of follow-up, we expect to confirm 1,208
incident PD cases with their neurologists. We will comprehensively examine the associations
between diet and lifestyle and risk of PD, focusing on dietary antioxidants, fat, caffeine,
dairy products, estrogen use, obesity, physical activity, and non steroidal
anti-inflammatory drugs (NSAIDs). Further, we will collect saliva samples from PD patients
and selected controls without PD for genetic analysis. These results will be used to explore
the PD associations with several common genetic polymorphisms and, for the first time, their
interactions with several promising diet or lifestyle exposures. Many of the specific aims
are novel and important but have been rarely examined in previous investigations. The
findings will improve our understanding of the complex relationships among diet, lifestyle,
gene-environment interaction, and PD etiology and may potentially contribute to successful
PD prevention strategies.

Study Aims:

1. Examine dietary factors that may increase or decrease PD risk.

2. Examine lifestyle factors that may increase or decrease PD risk.

3. Examine genetic polymorphisms in relation to PD risk and their interactions with diet

and lifestyle on PD risk.

Study Population: The NIH-AARP Diet and Health Study cohort.


1. Longitudinal study for the first two study aims

2. Nested case-control study for the third study aim.

Outcome Parameters: Physician confirmed PD diagnoses.

Inclusion Criteria


This study will be conducted within the infrastructure of the NIH-AARP Diet and Health
Study; every participant in the AARP cohort will be eligible for the current
investigation. Individuals with PD at baseline (prevalent cases) or with missing
information on exposure variables are still eligible for the study, but may be excluded
from specific analysis.

The proposed study does not require new recruitment.


No children are included.

The analytic sample includes all participants who respond to the follow-up questionnaires
and have non-missing values on the baseline surveys. Participants who reported PD before
exposure assessment may be excluded from the analyses.

Type of Study:


Study Design:


Principal Investigator

Honglei Chen, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Institute of Environmental Health Sciences (NIEHS)


United States: Federal Government

Study ID:




Start Date:

February 2006

Completion Date:

Related Keywords:

  • Parkinson's Disease (PD)
  • Diet
  • Lifestyle
  • Neurodegenerative Diseases
  • Elderly Population
  • Public Health
  • Parkinson Disease
  • Environment
  • Parkinson Disease



NIEHS, Research Triangle Park Research Triangle Park, North Carolina  27709