Inclusion Criteria:

- PCO - ESHRE/ASRM criteria: oligomenorrhea (<8 spontaneous menses per year) and
hyperandrogenism (hirsutism or acne) or hyperandrogenemia (testosterone >70ng/dl)

- Normal prolactin, TSH, 17-OH progesterone

- No evidence of androgen producing malignancy, Cushing’s syndrome or acromegaly

- Age 18-40

- Reliable use of birth control pill for at least 3 months and no plans of pregnancy

Exclusion Criteria:

- Elevated creatinine kinase above 2 times upper limit of normal or liver enzymes
(transaminases) above 2 times of upper limit of normal

- Use of any of the following medications: cyclosporine, fibrates, niacin, antifungal
agents, macrolide antibiotics.

- Use of oral contraceptives and other steroid hormones 3 months prior to the study

- Contraindications to oral contraceptives