The Diagnostic Performance of Screening Tests for the Diagnosis of Cushing's Syndrome
Cushing's syndrome is a rare disorder characterized by a variety of clinical signs and
symptoms that reflect chronic exposure to hypercortisolism such as obesity, hypertension,
glucose intolerance, infections, psychiatric disturbance, impaired cognition and
hypercoagulability. Thus, it is important to screen for this treatable disorder so as to
prevent its associated morbidity and mortality. Because many of the signs of Cushing's
syndrome are common in the general population, information about the cost-effectiveness and
diagnostic efficiency of various screening tests would be useful.
This study will evaluate the diagnostic performance of various screening tests for Cushing's
syndrome in overweight patients recruited from a weight loss center who have additional
signs of the disorder. Patients with abnormal tests will be seen as outpatients at the NIH
for further evaluation for up to two years to confirm or refute the possibility that they
have Cushing's syndrome. Patients with the disorder will be treated.
Lynnette K Nieman, M.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
United States: Federal Government
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Bethesda, Maryland 20892|
|GW University Medical Center GW Hospital Center||Washington, District of Columbia 20037|