Trial Information

Multiple Centers, Prospective, Phase II Trial of Gemcitabine and Docetaxel Combination Chemotherapy in Patients With Locally Advanced/Metastatic Soft Tissue Sarcoma or Imatinib Mesylate Refractory Advanced/Metastatic Malignant Gastrointestinal Stromal Tumor

Eligibility Criteria:

Inclusion criteria:

Patients must have a histologically confirmed diagnosis of (1) locally advanced unresectable
or metastatic soft tissue sarcoma; or (2) unresectable/metastatic GIST previously treated
with imatinib mesylate and is documented to have drug resistance to imatinib mesylate
treatment defined by tumor progression.

Age greater than or equal to 18 years and younger than or equal to 70 years old.

Measurable disease: defined as lesions that can be measured in at least one dimension by
physical examination or medical imaging techniques. Ascites, pleural effusions, and bone
marrow disease will not considered measurable disease.

Patients must have an ECOG performance status of less than or equal to 2. Patients must have
recovered (defined as toxicity less than grade 2) from toxic effects of all prior therapy
before entering onto study.

A treatment of drug free interval of at least 4 weeks since the last dose of chemotherapy or
imatinib mesylate therapy is required.

More than 4 weeks since prior radiotherapy is required. Adequate bone marrow function with
an ANC greater than or equal to 1,500/ml, platelet count greater than or equal to 100,000/
ml (transfusion independent) and hemoglobin greater than or equal to 8.0 g/dl (transfusions
permitted).

Patients must have adequate renal function with serum creatinine less than or equal to 1.5
mg/dl.

Patients must have adequate liver function, defined as bilirubin within 1.5 times the upper
limit of normal, and liver transaminases within 2.5 times the upper limit of normal.

All patients must sign a document of informed consent indicating their awareness of the
investigational nature and the risks of the study.

Exclusion criteria:

Patients who have prior treatment with gemcitabine or taxane. Pregnant or breast feeding
females. Active or uncontrolled infection. Patients with brain or leptomeningeal metastases.

Treatment Plan:

For safety and convenience of drug administration, a Port-A catheter implantation is
required before the start of the first chemotherapy course.

Gemcitabine 800 mg/m2 will be administered by intravenous infusion over 80 minutes on day 1
and day8, and docetaxel 60 mg/m2 over 60 minutes on day 1 of a 21-day cycle. After the first
cycle of the chemotherapy, if the ANC of the patient is always ≥ 1500/ml before the starting
of the next cycle, the dosage of docetaxel will be escalated to 75 mg/m2 on day 1 of the
next and following cycles.

All patients received filgrastim 300 mg subcutaneously once per day on day 12 to 15.

During treatment, complete blood cell counts are performed weekly. History and physical
examinations and assessment of toxicities are performed before each cycle of treatment.

Patients with progressive disease evaluated at the third or sixth course should be suggested
salvage treatment and withdrawn from protocol treatment.

Patients with SD, CR, or PR continue on study and undergo repeat CT scan after cycle 6.

Patients who have continued response at the sixth course will be given two additional
courses of chemotherapy, and undergo a CT scan again after cycle 8.

Dose Adjustments: dose adjustments were required in the following situations:

If patients experienced febrile neutropenia or had platelet count of less than 25,000/ml
lasting more than 5 days, doses of gemcitabine and docetaxel will be reduced to 75% of the
previous dose in all subsequent cycles.

If at day 1 of the treatment cycle the ANC is less than 1,500/ml or if the platelet count is
less than 50,000/ml, treatment will be delayed 1 week.

Patients in whom the ANC or platelet count has not recovered after a 2-week delay will be
removed from the study.

If on day 8 the ANC is 500 to 999/ul and the platelet is ≥ 50,000/ul, gemcitabine are
provided at 75% of the day 1 doses.

If at day 8 the ANC is less than 500/ul or if the platelet count is less than 50,000/ul,
gemcitabine at the day 8 dose will not be provided in that cycle.

If the patients experience grade 3 or 4 neurotoxicity, treatment will be delayed for 1 week.
If neurotoxicity has resolved to ≤ grade 2, treatment resumed with the docetaxel dose
decreases to 75% of the previous dose for all subsequent cycles.

If the patient's bilirubin level is more than 1.5 mg/dL, the docetaxel treatment will be
hold for that cycle. If bilirubin returns to ≤ 1.5 mg/dL, docetaxel treatment will be
resumed in the subsequent cycles.

If patients experienced other grade 3 or 4 nonhematologic toxicities (except alopecia),
treatment will be hold for up to 2 weeks; treatment will be resumed if nonhematologic
toxicity has resolved to ≤ grade 2.

Criteria for Withdrawal from Study Documented disease progression. A new cycle of
chemotherapy will be given if ANC ≥ 1500/ml, platelet count ≥ 50,000/ ml (transfusion
independent) and hemoglobin ≥ 8.0 g/dl (transfusions permitted). On the scheduled Day 1 of a
new treatment cycle, if the hemogram is not yet recovered, chemotherapy will be postponed
and the patient will be followed weekly until the resolution of toxicity. If the
interruption is more than 2 weeks from the schedule Day 1, the patient should be taken off
protocol treatment.

Occurrence of adverse event that the attending physician considers withdrawal from protocol
treatment is for the patient's optimal benefit.

Voluntary withdrawal.