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Prostate Cancer Screening and Dietary HA Exposure in African-Americans: Phase II


Phase 2
50 Years
70 Years
Open (Enrolling)
Male
Prostate Cancer

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Trial Information

Prostate Cancer Screening and Dietary HA Exposure in African-Americans: Phase II


OBJECTIVES:

- Estimate dietary heterocyclic amine (HA) exposure in African American men who use
HA-forming meats and cooking methods.

- Correlate dietary HA exposure with prostate-specific antigen and digital rectal exam
screening results (i.e., higher HA exposure with increased abnormality in prostate
cancer screening results) in these participants.

OUTLINE: This is a prospective study.

Participants complete a routine medical questionnaire and undergo a detailed dietary
interview that focuses on meat consumption, cooking preferences, and other factors that may
be associated with prostate cancer risk. Participants then undergo a digital rectal exam
(DRE) and blood collection for prostate-specific antigen (PSA) testing (total PSA and % free
PSA). Results of PSA testing and DRE, including follow-up instructions (if needed), are sent
to the participant 3-4 weeks later.

Blood samples are also examined by phenotypic assays for UV-damage induced nucleotide
excision-repair capacity.

PROJECTED ACCRUAL: A total of 800 participants will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- African American male

- No previous diagnosis of prostate cancer

- Desires prostate cancer screening as a routine preventative medical service

PATIENT CHARACTERISTICS:

- Lives in or near Oakland, California

- Speaks English

- No medical or other disability (e.g., blindness, psychological dysfunction, or
amputation) that would preclude study participation

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Interventional

Study Design:

Primary Purpose: Screening

Outcome Measure:

Dietary heterocyclic amine (HA) exposure in African American men

Safety Issue:

No

Principal Investigator

Kenneth T. Bogen, DrPH, MPH, MA, ScD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Lawrence Livermore National Laboratory at University of California

Authority:

Unspecified

Study ID:

CDR0000485428

NCT ID:

NCT00354497

Start Date:

March 2002

Completion Date:

Related Keywords:

  • Prostate Cancer
  • prostate cancer
  • Prostatic Neoplasms

Name

Location

Alta Bates Summit Medical Center - Summit CampusOakland, California  94609
Lawrence Livermore National Laboratory at University of CaliforniaLivermore, California  94550