Prostate Cancer Screening and Dietary HA Exposure in African-Americans: Phase II
- Estimate dietary heterocyclic amine (HA) exposure in African American men who use
HA-forming meats and cooking methods.
- Correlate dietary HA exposure with prostate-specific antigen and digital rectal exam
screening results (i.e., higher HA exposure with increased abnormality in prostate
cancer screening results) in these participants.
OUTLINE: This is a prospective study.
Participants complete a routine medical questionnaire and undergo a detailed dietary
interview that focuses on meat consumption, cooking preferences, and other factors that may
be associated with prostate cancer risk. Participants then undergo a digital rectal exam
(DRE) and blood collection for prostate-specific antigen (PSA) testing (total PSA and % free
PSA). Results of PSA testing and DRE, including follow-up instructions (if needed), are sent
to the participant 3-4 weeks later.
Blood samples are also examined by phenotypic assays for UV-damage induced nucleotide
PROJECTED ACCRUAL: A total of 800 participants will be accrued for this study.
Primary Purpose: Screening
Dietary heterocyclic amine (HA) exposure in African American men
Kenneth T. Bogen, DrPH, MPH, MA, ScD
Lawrence Livermore National Laboratory at University of California
|Alta Bates Summit Medical Center - Summit Campus||Oakland, California 94609|
|Lawrence Livermore National Laboratory at University of California||Livermore, California 94550|