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Myoma Microvascularization Analysis Using Sonovue Before and After Uterine Artery Embolization

18 Years
Open (Enrolling)

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Trial Information

Myoma Microvascularization Analysis Using Sonovue Before and After Uterine Artery Embolization

Before embolization of the uterine artery, 40 patients with unique or multiple myomas will
be included prospectively in our study and evaluated with sonography before and after
injection of Sonovue (2.4 ml) (Bracco Int Milano Italy). Pelvic ultrasound with contrast
enhancement will be done the day after and six months after the procedure.

Microvascularization of the myomas and the endometrium will be described. Some tiny myomas
which are not visible on conventional sonography could be identified for a perfect matching
with MRI detection.

Inclusion Criteria:

- Uterine myomas with solid tissue (greater diameter lower than 15 cm)

- The embolization is planified during the 15 days after the contrast ultrasonography

- Written informed consent is signed

Exclusion Criteria:

- Intracavitary uterine mass possibly due to a polyp or endometrial cancer

- Necessity of using the endovaginal way of ultrasonography because of the myoma's size
and accessibility

- Menopause

- Pregnancy and breastfeeding

- Recent cardiac affection

- History of acute cardiac disease

Type of Study:


Study Design:

Time Perspective: Prospective

Outcome Measure:

To investigate the usefulness of contrast-enhanced ultrasound with real-time imaging technique in the assessment of vascular patterns from myomas myometrium and ovaries before and after uterine artery embolization

Outcome Time Frame:

Inclusion period and follow-up

Principal Investigator

Henri MARRET, Pr

Investigator Role:

Principal Investigator

Investigator Affiliation:

Service de Gynécologie Obstétrique CHRU TOURS


France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:




Start Date:

July 2006

Completion Date:

June 2009

Related Keywords:

  • Myoma
  • embolization
  • contrast enhanced ultrasound
  • myoma
  • uterine artery
  • microvascularisation
  • Myoma