Inclusion Criteria

DISEASE CHARACTERISTICS:

- Healthy volunteer

PATIENT CHARACTERISTICS:

- ECOG performance status 0-2

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- Hemoglobin ≥ 12.0 g/dL (women)

- Hemoglobin ≥ 13.5 g/dL (men)

- WBC > 3,000/mm³

- Platelet count > 100,000/mm³

- Absolute neutrophil count > 1,500/mm³

- Alkaline phosphatase ≤ 1.5 times upper limit of normal (ULN)

- Bilirubin ≤ 1.5 times ULN

- ALT ≤ 1.5 times ULN

- Creatinine ≤ 1.5 times ULN OR creatinine clearance ≥ 30 mL/min

- No history of allergic reactions or hypersensitivity to sulindac or other NSAIDs,
including aspirin-sensitive asthma or urticaria

- No condition that interferes with ingestion or absorption of oral medications

- No cancer within the past 3 years except nonmelanomatous skin cancer, localized
prostate cancer, carcinoma in situ of the cervix, or superficial bladder cancer that
was previously treated > 6 months ago

- No uncontrolled concurrent illness including, but not limited to, the following:

- Ongoing or active infection

- Symptomatic congestive heart failure

- Unstable angina pectoris

- Cardiac arrhythmia

- Myocardial infarction in the past 6 months

- Chronic renal disease

- Chronic liver disease

- Hypertension that is difficult to control

- Psychiatric illness or social situations that would limit study compliance

- No other significant clinical disorder or laboratory finding that would preclude
study participation

- No consumption of alcoholic or caffeinated beverages for ≥ 24 hours prior to study
drug administration and until all blood samples have been drawn

- Willing to provide required biologic specimens

PRIOR CONCURRENT THERAPY:

- More than 6 months since prior investigational agents

- More than 6 months since prior regular use of (defined as a frequency of 7
consecutive days for > 3 weeks or > 21 days total) or other concurrent nonsteroidal
anti-inflammatory drugs (NSAIDs) or cyclooxygenase (COX)-2 inhibitors including, but
not limited to, the following:

- Ibuprofen

- Ketoprofen

- Naproxen

- More than 6 weeks since prior oral corticosteroids

- More than 30 days since prior and no concurrent use of any of the following:

- Methotrexate

- Corticosteroids

- Warfarin

- Ticlopidine

- Clopidogrel

- Low molecular weight heparins

- Abciximab

- Dipyridamole

- Eptifibatide

- Tirofiban

- Lithium

- Cyclosporine

- Hydralazine

- Angiotensin-converting enzymes (ACE) inhibitors

- ACE-receptor antagonists allowed

- Angiotensin-receptor blockers

- Ginkgo

- Ketorolac

- Levofloxacin

- Loop diuretics

- Meadowsweet

- Selective serotonin reuptake inhibitors

- Danaparoid

- No concurrent regular aspirin use unless prescribed by a physician for prevention

- A maximum of one aspirin (81 mg/day) allowed

- No concurrent herbal products (e.g., saw palmetto or Hypericum perforatum [St. John's
wort])