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Influence of Host Genetic Factors in Development of PML in an AIDS Cohort


N/A
N/A
N/A
Not Enrolling
Both
PML, AIDS

Thank you

Trial Information

Influence of Host Genetic Factors in Development of PML in an AIDS Cohort


The purpose of this study is to identify host genetic factors that contribute to the
development of Progressive Multifocal Leukoencephalopathy (PML) associated with JC virus.
JC virus is one of many opportunistic infections that arise in AIDS patients. JC virus is
widely distributed in the general population, with estimates of population exposure ranging
from 30-80%. JC virus remains latent in the host, and in profoundly immunosuppressed
patients, JC virus can cause PML, a fatal disease associated with neurotropic JC virus that
lytically infects oligodendrocytes. In untreated AIDS populations, the frequency of PML has
been estimated at roughly 5%. This study will identify host genetic factors that may
contribute to the development of PML in the AIDS population.

Inclusion Criteria


- No available subjects will be excluded.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

999905218

NCT ID:

NCT00342602

Start Date:

August 2005

Completion Date:

Related Keywords:

  • PML
  • AIDS
  • JC Virus
  • Opportunistic Infection
  • Single Nucleotide Polymorphism
  • Genotype
  • Sequencing
  • Acquired Immunodeficiency Syndrome
  • HIV Infections
  • Immunologic Deficiency Syndromes
  • Leukoencephalopathy, Progressive Multifocal
  • Leukoencephalopathies

Name

Location

John H. Stroger, Jr. Hospital of Cook CountyChicago, Illinois  60612-9985
University of PittsburghPittsburgh, Pennsylvania  15261
Northwestern UniversityChicago, Illinois  60611
University of California, Los AngelesLos Angeles, California  
Howard Brown Health CenterChicago, Illinois  60613
Johns Hopskins HospitalBaltimore, Maryland  21205