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In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients


N/A
18 Years
N/A
Not Enrolling
Both
Cell Function

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Trial Information

In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients


Peripheral blood mononuclear cells (PBMC) will be collected from healthy volunteers and
patients who present with different diseases that involve or implicate the immune system
dysregulation (HIV infection, autoimmune diseases and cancer). These PBMC will be studied
in vitro for a number of functional parameters, including generating soluable factors that
inhibit HIV infection, developing patterns of immune dysregulation, and inducing apoptotic T
cell death. The purpose of such studies is to obtain insight into the mechanisms of natural
resistance to viral infections, AIDS pathogenesis, and disease-induced immune dysregulation.

Inclusion Criteria


- INCLUSION CRITERIA:

Greater than or equal to 18 years old.

Documented HIV infection by current DoD criteria (1 ELISA, 2 Confirmatory Western Blot) or
by one of the following tests; DNA PCR, RNA PCR, p24 antigen test, viral culture assay.

CD4 lymphocyte cell count greater than 300 mm(3).

EXCLUSION CRITERIA:

Unable to provide informed consent.

Unable to meet the minimum (150 days) and maximum (395 days) research visit interval
requirements.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

999993010

NCT ID:

NCT00342485

Start Date:

April 1993

Completion Date:

March 2008

Related Keywords:

  • Cell Function
  • Cellular Immunity
  • HIV-infected
  • Immune Deficiency
  • Cancer
  • Transplantation

Name

Location

Willford Hall USAF Medical CenterSan Antonio, Texas  78236