Know Cancer

forgot password

The Second Multicenter Hemophilia Cohort Study

13 Years
Not Enrolling
Liver Decompensation, Hepatocellular Carcinoma, Non-Hodgkin Lymphoma

Thank you

Trial Information

The Second Multicenter Hemophilia Cohort Study

The Second Multicenter Hemophilia Cohort Study (MHCS-II) will evaluate and prospectively
follow approximately 4500 persons with hemophilia who were exposed to hepatitis C virus
(HCV). The vast majority will have been infected with HCV, and approximately 1/3 will have
been infected with human immunodeficiency virus (HIV). Primary objectives are to quantify
the rates of liver decompensation, hepatocellular carcinoma, and non-Hodgkin lymphoma and to
evaluate candidate clinical, genetic, virologic, serologic and immunologic markers that are
likely to be on the causal pathway for these conditions. Candidate clinical and laboratory
markers will be examined longitudinally to define changes over time and their relationships
to one another. Collaborative studies will focus on genome scanning and evaluation of
candidate genetic loci for susceptibility or resistance to HCV and HIV infections or to the
diseases that result from these infections. Additional studies will identify response and
complication rates of various anti-HCV and anti-HIV regimens in the setting of comprehensive
clinical care of persons with hemophilia.

Inclusion Criteria


Must be registered patient with an inherited coagulation disorder at a participating
MHCS-II center. Disorders include hemophilia A or B (congenital factor VIII or IX
deficiency), deficiencies in other factors such as V or XI, and vonWillebrand's disease.
(Unless noted otherwise, all of the disorders will collectively be referred to as
hemophilia .) All such hemophilia and vonWillebrand's disease patients are to be
recruited as study participants.

Since January 1, 1993, must have had at least one positive result on a licensed assay for
HCV antibodies, HIV antibodies, or HIV RNA.

Must be at least 13 years of age at enrollment.

Must provide signed informed consent or, for minors, signed assent plus signed informed
consent from the parent or guardian.


Is not a patient with an inherited coagulation disorder.

Does not have a positive test for HCV antibodies, HIV antibodies, or HIV RNA on a licensed
assay performed since January 1, 1993.

Is less than 13 years of age.

Lacks informed consent/assent.

Type of Study:


Study Design:


Principal Investigator

Wyndham H Wilson, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Institute (NCI)


United States: Federal Government

Study ID:




Start Date:

April 2001

Completion Date:

April 2013

Related Keywords:

  • Liver Decompensation
  • Hepatocellular Carcinoma
  • Non-Hodgkin Lymphoma
  • AIDS
  • Cancer
  • Hepatitis C Virus
  • HIV
  • Natural History
  • Hemophilia
  • Hepatitis C
  • Carcinoma
  • Hemophilia A
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Liver Failure
  • Carcinoma, Hepatocellular



Childrens National Medical Center Washington, District of Columbia  
Wake Forest University Winston-Salem, North Carolina  27103
Children's Hospital of Orange County Orange, California  92668
University of Colorado Denver, Colorado  80217
University of Oklahoma Oklahoma City, Oklahoma  73190
University of Minnesota Minneapolis, Minnesota  55455
Wayne State University Hutzel Hospital Detroit, Michigan  48201
University of California, San Francisco San Francisco, California  94143
University of Utah Salt Lake City, Utah  
University of Arizona Tucson, Arizona  85724
Vanderbilt University Nashville, Tennessee  37232-6305
University of North Carolina Chapel Hill, North Carolina  27599
University of Pennsylvania Philadelphia, Pennsylvania  19104
Georgetown University Washington, District of Columbia  20007-2197
Emory University Atlanta, Georgia  30322
Thomas Jefferson University Philadelphia, Pennsylvania  19107-6541
Ohio State University Columbus, Ohio  43210
University of New Mexico Albuquerque, New Mexico  87131
St. Louis University St. Louis, Missouri  63110
Mt. Sinai Medical Center New York, New York  10029
University of Cincinnati Cincinnati, Ohio  45267-0502
Childrens Memorial Hospital, Chicago Chicago, Illinois  60614
Cornell University New York, New York  10021
Wright State University Dayton, Ohio  45408
University of Illinois Chicago, Illinois  60612
University of Tennessee Memphis, Tennessee  38163
Childrens Hospital of Wisconsin Milwaukee, Wisconsin  53201
University of California, Davis Sacramento, California  95818
Tulane University New Orleans, Louisiana  70112-2699
Milton Hershey Medical Center Hershey, Pennsylvania  17033-2390
University of Texas, Houston Houston, Texas  77225
University of Texas, San Antonio San Antonio, Texas  78229-3900
Christiana Hospital Wilmington, Delaware  
St. Vincent's Hospital Indiannapolis, Indiana  
University of Mississippi Jackson, Mississippi  39216
University of Buffalo Buffalo, New York  
North Shore Long Island Jewish Health System Lake Success, New York  11042
Childrens Hospital, Cinncinati Cinncinati, Ohio  45229-3039
Palmentto Health Alliance Columbia, South Carolina  29202