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Study of Maternal and Umbilical Cord Hormone Concentrations in Monochorionic and Dichorionic Pregnancies

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Trial Information

Study of Maternal and Umbilical Cord Hormone Concentrations in Monochorionic and Dichorionic Pregnancies

Epidemiologic data are few but suggest that effects during the prenatal and early life
periods may be important in influencing risk of breast, prostate and testicular cancers
later in life. In particular, evidence is accumulating for associations with several
maternal, perinatal and pregnancy characteristics, including twining. The effect of these
factors may be mediated through alterations in hormone levels such as the estrogens and
other steroid hormones, to which the embryo and fetus are exposed during pregnancy.
Differences in maternal hormone concentrations by maternal and perinatal factors have been
noted, though data for most factors are sparse. Furthermore, less is known about the
relationships of pregnancy factors to hormones in cord blood, the proximal exposure to the
fetus, since most work thus far has been based on hormones in the maternal circulation. In
collaboration with investigators at Dartmouth Hitchcock Medical Center, we are collecting
maternal and cord blood samples from monochorionic twin, dichorionic twin and singleton
pregnancies of similar gestational age to quantify differences in concentrations of several
hormones and other pregnancy products. The purpose of the study is to assess the
consistency of these data with hypotheses regarding the altered cancer risk daughters of
twin pregnancies experience. All data collection is completed. We are currently analyzing
the data for development of manuscripts to be submitted for publication.

Inclusion Criteria


Eligible for study are pregnant women 18 years of age and older.

We will try to recruit women who do not have preeclampsia, chronic hypertension,
pre-pregnancy or gestational diabetes, thyroid disease or other major pregnancy


Eligible women who are pregnant with twins.

CONTROLS (Singletons):

Three control groups will be recruited: two for the mother of twins (one at the third
trimester, one at delivery), and one for the twins themselves at delivery.

A singleton pregnancy that meets the eligibility criteria and can be matched to the case
pregnancy on gestational age (within 1 week), parity (nulliparous vs. parous) and maternal
age (+/- 5 years) will be recruited for study.

Type of Study:


Study Design:


Principal Investigator

Rebecca Troisi, D.Sc.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Institute (NCI)


United States: Federal Government

Study ID:




Start Date:

November 2003

Completion Date:

Related Keywords:

  • Cancer
  • Twins
  • Estrogens
  • Androgens
  • Breast Cancer
  • In-Utero
  • Singletons
  • Angiogenic Factors
  • Umbilical Cord



Darmouth-Hitchcock Medical CenterLebanon, New Hampshire  03756