Prediagnostic Markers of Adult T-Cell Leukemia/Lymphoma Among Carriers of Human T-Lymphoma Virus Type I: A Collaborative Study
To characterize molecular markers for risk of adult T-cell leukemia/lymphoma (ATL), whose
incidence rate differs greatly across geographic areas, we propose to examine the prevalence
and level of viral and host immune response markers as well as the protein expression
pattern of 57 subjects who subsequently developed ATL and 171 matched control subjects who
participated in various prospective studies of carriers of human T-lymphotropic virus type I
(HTLV-I). Informative markers to be studied include provirus load, HTLV-I antibody titer,
anti-Tax protein, clonality of HTLV-I infected lymphocytes (viral markers), total
immunoglobulin E (IgE), C-reactive protein (CRP), neopterin, soluble CD30, soluble
interleukin-2 receptor (sIL2-R), EBV antibody profile (host immune markers), and proteomics.
These markers were selected based on the measurability on the majority of specimens,
availability of validated assays, relevance to the biology of T-cell malignancies, and has
been used in a cross-sectional comparison of HTLV-I carriers and non-carriers from Japan and
the Caribbean. We will utilize central laboratory and validated, standard assays for all
specimens. The results, unlinked to personal identifiers, will be analyzed using
generalized estimating equation. The findings will further our understanding of the
etiology of ATL, and of differences in natural history of HTLV-I infection across geographic
areas.
While pursuing the same theme of trying to identify host and viral markers associated with
ATL, the unique aspect of this proposal is to pool ATL cases, an extremely rare malignancy,
from multiple epidemiologic studies through international collaboration, in order to achieve
adequate statistical power and to perform valid comparison of tumor characteristics across
geographic areas.
Observational
N/A
United States: Federal Government
999905068
NCT00339638
December 2004
May 2011
Name | Location |
---|---|
University of California, San Francisco | San Francisco, California 94143 |
Harvard School of Public Health | Boston, Massachusetts 02115 |