A Population-Based Case-Control Study of Biliary Tract Cancers in Shanghai, China
The key aims of this study include estimation of possible risk associated with a history of
gallstones, bacterial infection for the biliary tract, other medical history, diet, use of
tobacco and alcohol, obesity, reproductive factors, and family history of cancer.
Information will be used to examine risk patterns a) seperately by anatomic subsite; b)
among patients with gallbladder cancer vs. controls undergoing cholecystectomy for
gallstones; c) among the patients with bile duct cancer vs. Hospital controls without
cancer who undergo surgery for removal of bile duct stones. We will also attempt to
ascertain reasons for cancer who undergo surgery for removal of bile duct stones. We will
also attempt to ascertain reasons for the rising incidence of biliary tract cancers in
Shanghai. Serum collected from all subjects will be analyzed for estrogens and other
hormones, vitamins C and E, cholesterol, and bacterial antibodies (including salmonella
typhi, paratyphi, and escherischia coli). Bile fluid will be cultured for aerobic bacteria,
and gallstones analyzed for color, cholesterol, and evidence of bacteria infection. A major
challenge in biliary tract cancer research is to determine how cancer risk factors differ
from those for gallstones or biliary duct stone disease, since many people have gallstones
(or biliary duct stones) but few develop cancer.
Jill E. Koshiol, M.D.
National Cancer Institute (NCI)
United States: Federal Government