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Incidence and Mortality of Childhood Cancer Among Children of Farmer Pesticide Applicators


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Not Enrolling
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Pesticide Exposure

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Trial Information

Incidence and Mortality of Childhood Cancer Among Children of Farmer Pesticide Applicators


Previous studies have estabished pesticide exposure as a possible risk factor for childhood
cancer. The Agricultural Health Study (AHS), a prospective cohort study of pesticide
exposure among 51,000 pesticide applicators in North Carolina and Iowa, provides an
opportunity to study childhood cancer incidence and mortality among the children of
pesticide applicators. Name and dates of birth for 21,985 children were previously provided
by adult participants in the AHS. The current study seeks to identify cases of cancer among
these children through record linkage to state cancer and death registries. Cancer
incidence and mortality within the cohort will be compared with national data through
standardized incidence and mortality ratios. A limited case-cohort comparison of pesticide
exposures will also be performed. Approximately 44 cases of childhood cancer are expected
to be identified. No follow-up or contact with cases is anticipated. It is anticipated
that the study results will provide insight into the relationship of pesticide and other
farm exposures to the pathogenesis of childhood cancer.

Inclusion Criteria


- INCLUSION CRITERIA:

Subjects will be included in the study if they are children of private pesticide
applicators who participated in the AHS, and were born between 1975 and 1996.

EXCLUSION CRITERIA:

Subjects with age greater than 19 years during this period will be excluded as the outcome
under study is childhood cancer.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

999900025

NCT ID:

NCT00339378

Start Date:

June 2000

Completion Date:

June 2007

Related Keywords:

  • Pesticide Exposure
  • Record Linkage
  • Retrospective
  • Cohort
  • Registries
  • Agricultural

Name

Location

National Cancer InstituteBethesda, Maryland  20892-1922
Environmental Protection AgencyResearch Triangle Park, North Carolina  27711
NIEHS, Research Triangle ParkResearch Triangle Park, North Carolina  27709