Inclusion Criteria:

- Histologically confirmed surgically incurable metastatic melanoma

- Patients must have measurable disease

- ECOG performance status of 0 or 1

- Expected life expectancy at least 4 months

Exclusion Criteria:

- History of and signs/symptoms of uncontrolled brain metastases or edema.

- Previous treatment with chemotherapy or any biological anti-cancer drug (prior
adjuvant therapy with interferon-alpha is permitted as long as treatment was
completed at least six months prior to study entry.)

- Radiotherapy: Radiation therapy within 4 weeks prior to entering the study.

- Receipt of any investigational drug for treatment of metastatic melanoma prior to
this trial.