A RENEW Intervention for Elderly Cancer Survivors
- Compare the perception of, and the patterns of change in fatigue, weakness, physical
activity level, and functional status in elderly cancer survivors who undergo
Resistance Exercise via Negative-Eccentric Work (RENEW) vs standard care.
- Compare changes in muscle structure, function (strength + power production and
metabolic function) and mobility.
- Evaluate the patient's adherence to and satisfaction with the RENEW intervention.
OUTLINE: This is a prospective, randomized, controlled, longitudinal study. Patients are
randomized to 1 of 2 intervention arms.
- Arm I: Patients undergo resistance exercise via negative-eccentric work (RENEW), using
a special seated stationary leg exercise machine, 3 times a week for up to 12 weeks.
Exercise exertion and duration is gradually increased weekly for the first 4-5 weeks of
- Arm II: Patients receive standard care. In both arms, fatigue, weakness, physical
activity, functional status, muscle structure and function, and mobility are assessed
at baseline and then at 12 weeks after completion of study intervention. Fatigue and
weakness are also assessed weekly during study intervention. Patients in arm I also
undergo isometric strength assessment weekly during RENEW and assessment of adherence
to and satisfaction with RENEW at 12 weeks after completion of RENEW.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Supportive Care
Patient perception and pattern of change
To explore the participant's perception and pattern of change in fatigue, weakness, physical activity level and functional status
3 months of training followed by 6 and 12 months of no formal training
Paul C. LaStayo, PhD, PT
University of Utah
United States: Federal Government
|Huntsman Cancer Institute at University of Utah||Salt Lake City, Utah 84112|