A Prospective Double Blinded Study on the Effect of Intravenously Administrated Nitroglycerine on Gastric Tissue Microvascular Bloodflow and Microvascular Hemoglobin Saturation During Gastric Tube Reconstruction
Complications of oesophagectomy and gastric tube reconstruction are leakage and stenosis,
which may be due to compromised microvascular blood flow (MBF) in the gastric tissue. We
recently demonstrated that peri-operatively decreased MBF could be improved by topical
administration of nitro-glycerine NTG). In this present study we investigate the effect of
intravenous NTG on gastric microcirculation.
This single centre, prospective, double blinded study randomized thirty-two patients
scheduled for esophagectomy into two groups. The intervention group received intravenous NTG
during gastric tube reconstruction, as the control group received normal saline.
Baseline values of MBF, microvascular haemoglobin O2 saturation (μHbSO2), and microvascular
haemoglobin concentration (μHbcon) were determined at the gastric fundus before and after
gastric tube construction and after pulling up the gastric tube to the neck.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention
differences in Microvascular bloodflow
Diederik Gommers, MD, PhD
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)