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The Effect of Cinnamon Extract on Insulin Resistance Parameters in Polycystic Ovary Syndrome: A Pilot Study

Phase 1
23 Years
47 Years
Not Enrolling
Polycystic Ovary Syndrome

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Trial Information

The Effect of Cinnamon Extract on Insulin Resistance Parameters in Polycystic Ovary Syndrome: A Pilot Study

Polycystic ovary syndrome (PCOS) is a very common condition found in women of childbearing
age. PCOS patients often have irregular periods, extra hair growth, or difficulty becoming
pregnant. The syndrome can also be associated with more serious conditions such as heart
disease, diabetes, or cancer of the uterus.

Although no one knows the cause of the syndrome, scientific studies showed that having too
much insulin can be one of the reasons. In fact, almost every overweight woman with PCOS has
been found to have high insulin levels.

Medications that lower the body's insulin level used to treat people with diabetes mellitus
have also been used very successfully to treat some of the symptoms of PCOS such as
irregular periods.

Recently studies using rats and mice have shown that a commonly used spice, cinnamon, may
also reduce the body's insulin level. Another study showed that daily use of cinnamon for
forty days lowered the blood sugar level in patients with diabetes. The purpose of this
study is to see if cinnamon can lower the insulin level in women with PCOS. If so, it can
also be used as a treatment for irregular periods as well.

Half of the patients in the study will take premade cinnamon extract pills twice a day while
the other half will take placebo pills (pills with no cinnamon extract) twice a day for
eight weeks. Blood tests measuring insulin, substances important for insulin action,
cholesterol, and glucose (sugar) will be taken before and after the eight weeks of
medication. A total of three separate visits will be needed to finish the study. At the end
of the study, we will then compare the blood glucose, insulin, and cholesterol levels
between the patients that took cinnamon and the patients that took placebo.

Inclusion Criteria:

- Polycystic ovary syndrome

Exclusion Criteria:

- Diabetes mellitus, hyperprolactinemia, thyroid disorders, and hypertension

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

Fasting glucose

Outcome Time Frame:

Duration of study

Safety Issue:


Principal Investigator

Rogerio Lobo, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Columbia University


United States: Institutional Review Board

Study ID:




Start Date:

August 2005

Completion Date:

February 2006

Related Keywords:

  • Polycystic Ovary Syndrome
  • polycystic ovary syndrome
  • insulin resistance
  • cinnamon
  • Insulin Resistance
  • Polycystic Ovary Syndrome



Center for Women's Reproductive CareNew York, New York  10019