Incidence of Osteoporosis in Children With Acute Lymphoblastic Leukemia Undergoing Therapy
Osteoporosis is a disease characterized by low bone mass and microarchitectural
deterioration of bone tissue. Osteoporosis is a devastating disorder with significant
physical, psychosocial and financial consequences. Intensive chemotherapy and radiotherapy
have led to significant improvements in long term, disease-free survival of children with
malignancies. Unfortunately, there are many deleterious side effects associated with this
therapy. Little is known about the longitudinal changes in bone mass accumulation and bone
metabolism in these patients.
The purpose of this study is to evaluate the timing and severity of changes in bone mineral
metabolism for children treated for childhood leukemia. Data will be used to establish
treatment protocols with the goal of preventing severe fractures and pain in the acute
treatment stage and severe osteoporosis and related pathology in the chronic stage.
Observational
Observational Model: Defined Population, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Prospective
Jadranka Popovic, MD
Principal Investigator
Children's Mercy Hospital
United States: Institutional Review Board
03 08-085
NCT00330538
March 2004
October 2006
Name | Location |
---|---|
Children's Mercy Hospital | Kansas City, Missouri 64108 |