Inclusion Criteria:

Patients must meet all of the following inclusion criteria:

- Histologically proven cancer

- Patients must have adequate bone marrow, renal, hepatic and pulmonary function.

- World Health Organization (WHO) performance status of 0 or 1

- > 18 years of age

- Patients who have given their signed and written informed consent to participate in
the trial after fully understanding the implication of the protocol

- Women receiving any cytotoxic drug during pregnancy are allowed for the assessment of
the maternal and fetal outcome

- Patients are allowed to opt for the pharmacokinetic part or clinical follow-up part
of the study only and do not need to participate in both; however, preferentially
both study parts should be performed.

- Women receiving any kind of radiotherapy during pregnancy

Exclusion Criteria:

- Mentally disabled or significantly altered mental status that would prohibit the
understanding and giving of informed consent