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Killer T Cell Activity in the Paraneoplastic Neurologic Syndromes

16 Years
Open (Enrolling)
Paraneoplastic Syndromes

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Trial Information

Killer T Cell Activity in the Paraneoplastic Neurologic Syndromes

Patients with paraneoplastic neurological disorders (PNDs) provide a unique model for
studying tumor immunity and neuronal autoimmunity. We hypothesize that T lymphocyte
autoimmune dysfunction is involved in the pathogenesis of the paraneoplastic neurological
syndromes, and that killer T cells are involved in the targeting and successful killing of
tumor cells in these cancer patients. Furthermore, we postulate that this activity may
provide a model for autoimmune brain disease. We will assess the immune responses in PND
patients, correlate these with the clinical data (time course of disease, symptoms and
signs, disability), and collect and archive clinical data, serum and cells from PND patients
for current and future studies into the basic immune system phenomenon present in PND

Inclusion Criteria:

- Neurological disease which is suspected to be paraneoplastic

- No known active additional malignancy other than non-melanoma skin cancer

Exclusion Criteria:

- Known central nervous system (CNS) metastasis

- Known active additional malignancy

if leukapheresis: No known hepatitis B or C, HIV, or syphilis (by history or prior
negative tests) no known IV drug users HgB > 8.5 WBC > 3,500 platelets > 100,000 INR < 2

if large blood draw (1/2 to 1 unit; children 3 ml/kg) in lieu of leukapheresis: no known
IV drug users HgB > 10 WBC > 3,500 platelets > 100,000 INR < 2 if lumbar puncture:
platelets > 120,000 INR < 1.2

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Robert Darnell, MD, PHD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Rockefeller University


United States: Institutional Review Board

Study ID:




Start Date:

January 1995

Completion Date:

December 2015

Related Keywords:

  • Paraneoplastic Syndromes
  • Paraneoplastic Neurologic Syndromes
  • Paraneoplastic Syndromes
  • Paraneoplastic Syndromes, Nervous System



Rockefeller University Hospital New York, New York  10021-6399