Killer T Cell Activity in the Paraneoplastic Neurologic Syndromes
Patients with paraneoplastic neurological disorders (PNDs) provide a unique model for
studying tumor immunity and neuronal autoimmunity. We hypothesize that T lymphocyte
autoimmune dysfunction is involved in the pathogenesis of the paraneoplastic neurological
syndromes, and that killer T cells are involved in the targeting and successful killing of
tumor cells in these cancer patients. Furthermore, we postulate that this activity may
provide a model for autoimmune brain disease. We will assess the immune responses in PND
patients, correlate these with the clinical data (time course of disease, symptoms and
signs, disability), and collect and archive clinical data, serum and cells from PND patients
for current and future studies into the basic immune system phenomenon present in PND
patients.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Robert Darnell, MD, PHD
Principal Investigator
Rockefeller University
United States: Institutional Review Board
RDA-0148
NCT00327236
January 1995
December 2015
Name | Location |
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Rockefeller University Hospital | New York, New York 10021-6399 |