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A Phase I Clinical Trial of AZD2171 in Children With Recurrent or Progressive Central Nervous System (CNS) Tumors


Phase 1
N/A
21 Years
Open (Enrolling)
Both
Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor, Childhood Grade I Meningioma, Childhood Grade II Meningioma, Childhood Grade III Meningioma, Childhood High-grade Cerebral Astrocytoma, Childhood Infratentorial Ependymoma, Childhood Low-grade Cerebral Astrocytoma, Childhood Oligodendroglioma, Childhood Spinal Cord Neoplasm, Childhood Supratentorial Ependymoma, Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Brain Tumor, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Medulloblastoma, Recurrent Childhood Pineoblastoma, Recurrent Childhood Subependymal Giant Cell Astrocytoma, Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor, Recurrent Childhood Visual Pathway and Hypothalamic Glioma

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Trial Information

A Phase I Clinical Trial of AZD2171 in Children With Recurrent or Progressive Central Nervous System (CNS) Tumors


PRIMARY OBJECTIVES:

I. Determine the maximum tolerated dose of AZD2171 in pediatric patients with recurrent,
progressive, or refractory primary CNS tumors.

II. Describe the toxicity profile and dose-limiting toxicities of AZD2171 in these patients.

SECONDARY OBJECTIVES:

I. Characterize inter-patient variability in the pharmacokinetics of AZD2171 in these
patients.

II. Describe changes in circulating endothelial cells (CECs) and circulating endothelial
cell precursors (CEPs) in patients treated with AZD2171 at different dose levels.

III. Correlate changes in CECs, CEPs, plasma, serum, and urine levels of proteins with
angiogenesis, including vascular endothelial growth factor (VEGF) and VEGF receptor, in
patients treated with AZD2171 at different dose levels.

IV. Correlate changes in CECs, CEPs, and angiogenic modulators with changes in magnetic
resonance (MR) perfusion.

V. Obtain preliminary evidence of biologic activity of AZD2171 by evaluating alterations in
tissue perfusion, tumor blood flow, and metabolic activity using MR perfusion and diffusion
imaging, and positron-emission tomography, and correlating these findings with changes in
tumor size by standard MRI.

OUTLINE: This is a dose-escalation, multicenter study. Patients are stratified according to
concurrent enzyme-inducing anticonvulsant drugs (yes vs no).

Patients receive oral AZD2171 once daily on days 1-28. Treatment repeats every 28 days for
up to 13 courses in the absence of disease progression or unacceptable toxicity.

For each stratum, cohorts of 2-6 patients receive escalating doses of AZD2171 until the
maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which 25% of
patients experience dose-limiting toxicity. Once the MTD is determined, an additional 6
patients per stratum are enrolled and treated at the MTD.

After completion of study, patients are followed at 30 days.


Inclusion Criteria:



- Histologically confirmed primary CNS tumor

- Histologically benign brain tumors (e.g., low-grade glioma) allowed

- Histological requirement waived for intrinsic brain stem or diffuse optic
pathway tumors, but must have clinical and/or radiographic evidence of
progression

- Recurrent, progressive, or refractory disease

- Absolute neutrophil count >= 1,000/mm^3 (unsupported)

- Platelet count >= 75,000/mm^3 (unsupported)

- Creatinine =< 1.5 times upper limit of normal (ULN) OR glomerular filtration rate >=
70 mL/min

- Bilirubin =< 1.5 times ULN

- ALT =< 2.5 times ULN

- Urine dipstick or urinalysis < 1+ protein

- Albumin >= 3 g/dL

- Karnofsky performance status (PS) 60-100% (> 16 years of age) OR Lansky PS 60-100%
(=< 16 years of age)

- Karnofsky/Lansky PS 70-100% for patients at increased risk for compromised LVEF

- Hemoglobin >= 8 g/dL (transfusion support allowed)

- No overt renal, hepatic, cardiac, or pulmonary disease

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- QTc prolongation =< 500 msec

- No other significant ECG abnormality within the past 14 days

- No clinically significant, unrelated, systemic illness, including serious infections
or significant cardiac, pulmonary, hepatic, or other organ dysfunction, that would
preclude study participation

- No uncontrolled hypertension

- Defined as systolic and diastolic BP > 95th percentile for age (ages 1-17)

- Defined as BP > 140/90 (ages 18 and older)

- No New York Heart Association class III or IV disease and Karnofsky/Lansky PS < 70

- Class II disease controlled with treatment and increased monitoring is allowed

- Recovered from all prior therapy

- No prior AZD2171

- At least 3 weeks since prior myelosuppressive anticancer chemotherapy (6 weeks for
nitrosoureas)

- More than 1 weeks since prior investigational or biologic agents

- If the investigational or biologic agent has a prolonged half-life (> 48 hours),
then these patients must be discussed with the study chair prior to registration

- No concurrent drugs or biologics with proarrhythmic potential

- More than 3 months since last fraction of craniospinal radiotherapy or total-body
irradiation

- More than 4 weeks since last fraction of focal irradiation to symptomatic metastatic
sites

- At least 6 months since prior allogeneic bone marrow transplantation

- At least 3 months since prior autologous bone marrow or stem cell transplantation

- At least 1 week since prior filgrastim (G-CSF), sargramostim (GM-CSF), or epoetin
alfa (2 weeks for pegfilgrastim)

- No other concurrent investigational agents

- Concurrent dexamethasone allowed provided patient is on a stable or decreasing dose
for ≥ 1 week before study entry

- No concurrent chemotherapy

- No concurrent routine use of G-CSF, GM-CSF, or epoetin alfa

- Able to swallow tablets

- Any neurologic deficits must be stable for >= 1 week

- If the investigational or biologic agent has a prolonged half-life (> 48 hours), then
these patients must be discussed with the study chair prior to registration

Exclusion Criteria:

- No known curative therapy available

Type of Study:

Interventional

Study Design:

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Maximum tolerated dose, defined as the dose at which the model estimates that 25% of patients will experience dose-limiting toxicity as measured by NCI CTCAE v4.0

Outcome Description:

Estimated using the modified Continual Reassessment Method (CRM).

Outcome Time Frame:

42 days

Safety Issue:

Yes

Principal Investigator

Mark Kieran

Investigator Role:

Principal Investigator

Investigator Affiliation:

Pediatric Brain Tumor Consortium

Authority:

United States: Food and Drug Administration

Study ID:

NCI-2009-00709

NCT ID:

NCT00326664

Start Date:

March 2006

Completion Date:

Related Keywords:

  • Childhood Atypical Teratoid/Rhabdoid Tumor
  • Childhood Central Nervous System Germ Cell Tumor
  • Childhood Grade I Meningioma
  • Childhood Grade II Meningioma
  • Childhood Grade III Meningioma
  • Childhood High-grade Cerebral Astrocytoma
  • Childhood Infratentorial Ependymoma
  • Childhood Low-grade Cerebral Astrocytoma
  • Childhood Oligodendroglioma
  • Childhood Spinal Cord Neoplasm
  • Childhood Supratentorial Ependymoma
  • Recurrent Childhood Brain Stem Glioma
  • Recurrent Childhood Brain Tumor
  • Recurrent Childhood Cerebellar Astrocytoma
  • Recurrent Childhood Cerebral Astrocytoma
  • Recurrent Childhood Ependymoma
  • Recurrent Childhood Medulloblastoma
  • Recurrent Childhood Pineoblastoma
  • Recurrent Childhood Subependymal Giant Cell Astrocytoma
  • Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor
  • Recurrent Childhood Visual Pathway and Hypothalamic Glioma
  • Astrocytoma
  • Brain Neoplasms
  • Neoplasms
  • Ependymoma
  • Glioma
  • Medulloblastoma
  • Meningioma
  • Oligodendroglioma
  • Spinal Cord Neoplasms
  • Neoplasms, Germ Cell and Embryonal
  • Pinealoma
  • Neuroectodermal Tumors
  • Neuroectodermal Tumors, Primitive
  • Rhabdoid Tumor
  • Optic Nerve Glioma

Name

Location

Pediatric Brain Tumor ConsortiumMemphis, Tennessee  38105