Inclusion Criteria

- INCLUSION CRITERIA:

Patients must have histologically confirmed (by NIH pathology department) solid tumor
malignancy or lymphoma that is metastatic or unresectable and for which there is not
therapy with survival benefit and standard curative or palliative measures do not exist.

Patients must have measurable or evaluable disease.

Patients must have recovered less than or equal to grade 1 toxicity levels due to adverse
events and/or toxicity of prior chemotherapy or biologic therapy. They must not have had
chemotherapy or biologic therapy within 4 weeks prior to entering the study (6 weeks for
nitrosoureas or mitomycin C, 8 weeks for UCN-01). Patients must be at least 1 month since
any prior radiation or major surgery. Patients must be greater than or equal to 2 weeks
since any prior participation in a Phase Zero study. Patients on bisphosphonates for any
cancer or on androgen deprivation therapy for prostate cancer, however, will not need to
discontinue this therapy in order to be eligible.

Age greater than or equal to 18 years.

ECOG performance status less than or equal to 2 (Karnofsky greater than or equal to 60%,
see Appendix A).

Life expectancy of greater than 3 months.

Patients must have normal or adequate organ and marrow function as defined below:

- Hb greater than or equal to 10 g/dL

- absolute neutrophil count greater than or equal to 1,500/ L

- platelets greater than or equal to 100,000/ L

- total bilirubin less than or equal to 1.5 normal institutional limits

- AST (SGOT)/ALT (SGPT) less than or equal to 2.5 x institutional upper limit of normal

- creatinine clearance less than 1 x upper limit of normal

OR

-creatinine clearance greater than or equal to 60 mL/min/1.73 m(2) for patients with
creatinine levels above institutional normal.

The effects of CDDO on the developing human fetus are unknown. For this reason, women of
child-bearing potential and men must agree to use adequate contraception (hormonal or
barrier method of birth control or abstinence) prior to study entry and for the duration
of study participation and for 2 months after discontinuation of the study. Women of child
bearing potential must have a negative pregnancy test in order to be eligible. Should a
woman become pregnant or suspect she is pregnant while participating in this study, she
should inform her treating physician immediately. Because there is an unknown but
potential risk for adverse events in nursing infants secondary to treatment of the mother
with CDDO, breastfeeding should be discontinued if the mother is treated with CDDO.

Ability to understand and the willingness to sign a written informed consent document.

EXCLUSION CRITERIA:

Patients receiving any other investigational agents.

Patients with known brain metastases are excluded from this clinical trial, with the
exception of patients whose brain metastatic disease status has remained stable for at
least 6 months after treatment of the brain metastases without steroids or anti-seizure
medications. These patients may be enrolled at the discretion of the principal
investigator.

History of allergic reactions attributed to other synthetic triperinoids or compounds of
similar chemical or biologic composition to CDDO, such as derivative compounds
1-[2-cyano-3-,12- dioxooleana -1,9-dien-28-oyl] imidazole (CDDO-Im), and C-28 methyl ester
of 2-cyano-3,12-dioxoolen-1,9-dien-28-oic acid (CDDO-Me).

Patients with clinically significant illnesses which could compromise participation in the
study, including, but not limited to: Active or uncontrolled infection, immune
deficiencies or confirmed diagnosis of HIV infection, Hepatitis B, Hepatitis C, or
uncontrolled diabetes, uncontrolled hypertension, symptomatic congestive heart failure,
unstable angina pectoris, myocardial infarction within the past six months, uncontrolled
cardiac arrhythmia; or psychiatric illness/social situations that would limit compliance
with study requirements.