Know Cancer

or
forgot password

Adenoma-Carcinoma Sequence in the Ileal Pouch Anal Anastomosis in Patients With Familial Adenomatous Polyposis: Studies on Luminal and Mucosal Risk Factors and Chemoprevention


Phase 2
16 Years
N/A
Open (Enrolling)
Both
Adenomatous Polyposis Coli

Thank you

Trial Information

Adenoma-Carcinoma Sequence in the Ileal Pouch Anal Anastomosis in Patients With Familial Adenomatous Polyposis: Studies on Luminal and Mucosal Risk Factors and Chemoprevention


Inclusion Criteria:



- Clinically or genetically proven familial adenomatous polyposis

- Restorative proctocolectomy with ileal pouch anal anastomosis

Exclusion Criteria:

- Chronic or acute renal or hepatic disease

- History of oesophageal, gastric or duodenal ulcers

- Known hypersensitivity to sulindac

- Daily use during the last three months of:

- Aspirin

- Non-Steroidal Anti-Inflammatory Agents

- Probiotics

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention

Outcome Measure:

Pouch mucosal proliferation index at 0, 1 and 2 months

Principal Investigator

Fokko M Nagengast, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Radboud University

Authority:

Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:

23266

NCT ID:

NCT00319007

Start Date:

April 2006

Completion Date:

December 2006

Related Keywords:

  • Adenomatous Polyposis Coli
  • Adenoma
  • Adenomatous Polyposis Coli

Name

Location