Gene Expression Analysis in Thyroid Nodule FNA Samples
- Evaluate the diagnostic accuracy of biomarkers and mRNA expression analysis using
fine-needle aspiration (FNA) biopsy samples from patients with thyroid nodules.
- Correlate the level of gene expression with the aggressiveness of differentiated
thyroid cancer in FNA biopsy samples.
OUTLINE: Patients undergo fine-needle aspiration (FNA) biopsy as part of routine care.
Additional thyroid tissue is collected during the biopsy for gene expression analysis.
Patients who have already had a biopsy undergo FNA biopsy during thyroidectomy.
Tissue samples will be examined for gene expression by reverse transcriptase-polymerase
chain reaction (PCR), real-time quantitative PCR, and immunohistochemistry.
PROJECTED ACCRUAL: A total of 400 patients will be accrued for this study.
Masking: Open Label, Primary Purpose: Diagnostic
Diagnostic accuracy of biomarkers by mRNA expression analysis
Electron Kebebew, MD
University of California, San Francisco
|UCSF Helen Diller Family Comprehensive Cancer Center||San Francisco, California 94115|