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A Phase II Study of Intravenous Melphalan and Busulfan Followed by HLA-Matched, Allogeneic Peripheral Blood Stem Cell Transplant for the Treatment of Multiple Myeloma


Phase 2
18 Years
60 Years
Not Enrolling
Both
Multiple Myeloma and Plasma Cell Neoplasm

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Trial Information

A Phase II Study of Intravenous Melphalan and Busulfan Followed by HLA-Matched, Allogeneic Peripheral Blood Stem Cell Transplant for the Treatment of Multiple Myeloma


OBJECTIVES:

Primary

- Evaluate transplant-related mortality in patients with multiple myeloma treated with a
myeloablative conditioning regimen comprising melphalan and busulfan followed by
HLA-matched, allogeneic peripheral blood stem cell transplantation (PBSCT) and
graft-vs-host disease prophylaxis with tacrolimus and methotrexate.

Secondary

- Determine the disease response in patients treated with this regimen.

- Determine the 1-year progression-free survival and overall survival in patients treated
with this regimen.

OUTLINE:

- Conditioning regimen: Patients receive melphalan IV over 30 minutes on day -6 and
busulfan IV over 3 hours on days -5 to -3.

- Peripheral blood stem cell transplantation (PBSCT): Patients undergo HLA-matched,
related donor, allogeneic PBSCT on day 0.

- Graft-versus-host disease (GVHD) prophylaxis: Patients receive tacrolimus IV
continuously or orally twice daily beginning on day -2 and continuing until day 80
followed by a taper until day 180 in the absence of GVHD or disease progression.
Patients also receive methotrexate IV on days 1, 3, 6, and 11.

After completion of study treatment, patients are followed every 6 months for 2 years and
then annually thereafter.

PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of multiple myeloma

- Stage I disease with disease progression during the second of ≥ 2 lines of prior
therapy

- Stage II or III disease, meeting 1 of the following criteria:

- Failed to achieve at least a partial response after ≥ 2 courses of prior
therapy

- Progressive disease after ≥ 2 courses of prior therapy

- Presented with high-risk features at diagnosis, including any of the
following:

- Cytogenetic abnormality

- Del 13 or 4,14 by fluorescent in situ hybridization (FISH)

- Elevated lactic dehydrogenase

- Beta 2 microglobulin > 5.5

- Circulating peripheral blood plasma cells

- Any stage disease with disease progression > 6 months after prior autologous
stem cell transplantation

- Availability of an HLA-matched, related donor between 12 and 75 years of age*

- No bone marrow donors NOTE: *Donors > 75 years of age are eligible at the
discretion of the principal investigator

PATIENT CHARACTERISTICS:

- Karnofsky performance status 70-100%

- Creatinine clearance > 60 mL/min

- Bilirubin ≤ 2.5 mg/dL

- ALT/AST < 2 times upper limit of normal

- Cardiac ejection fraction ≥ 49%

- DLCO ≥ 50% corrected

- FEV_1 ≥ 60%

- Not pregnant or nursing

- Fertile patients must use effective contraception

- HIV negative

- No cirrhosis

- No chronic inflammatory or fibrotic liver disease

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- At least 6 months since prior autologous transplantation

Type of Study:

Interventional

Study Design:

Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Transplant-related mortality at 180 days

Safety Issue:

No

Principal Investigator

William I. Bensinger, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fred Hutchinson Cancer Research Center

Authority:

United States: Federal Government

Study ID:

2018.00

NCT ID:

NCT00313625

Start Date:

September 2005

Completion Date:

Related Keywords:

  • Multiple Myeloma and Plasma Cell Neoplasm
  • stage I multiple myeloma
  • stage II multiple myeloma
  • stage III multiple myeloma
  • refractory multiple myeloma
  • Neoplasms
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Plasmacytoma

Name

Location

Fred Hutchinson Cancer Research Center Seattle, Washington  98109