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Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma?


N/A
40 Years
N/A
Not Enrolling
Both
Glaucoma

Thank you

Trial Information

Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma?


Inclusion Criteria:



- Men and women older than 39 years

- Primary open angle glaucoma as evidenced from characteristic visual field loss and
optic disc cupping (POAG group)

- Healthy subjects matched by age, sex and ethnicity to the POAG patients group
(control group)

Exclusion Criteria:

- Exfoliation glaucoma, pigmentary glaucoma

- History of acute angle closure

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Genotyping results and putatively associated odds with occurence of primary open angle glaucoma.

Outcome Time Frame:

15 minutes

Safety Issue:

No

Principal Investigator

Gabriele Fuchsjaeger-Mayrl, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Clinical Pharmacology, Medical University of Vienna

Authority:

Austria: Federal Ministry for Health and Women

Study ID:

OPHT-300505

NCT ID:

NCT00312403

Start Date:

November 2005

Completion Date:

December 2009

Related Keywords:

  • Glaucoma
  • Glaucoma
  • Gene Polymorphism
  • Metalloproteinase
  • Glaucoma
  • Glaucoma, Open-Angle

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