Know Cancer

forgot password

Tissue and Data Acquisition Activity for the Study of Gynecological Disease

18 Years
Open (Enrolling)
Endometrial Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Leiomyoma

Thank you

Trial Information

Tissue and Data Acquisition Activity for the Study of Gynecological Disease

Cancer arises due to genetic alterations that disrupt numerous cellular functions including
proliferation, programmed cell death and senescence, that ultimately control the number of
cells in a population. The genetic damage that underlies the development of cancers has a
diverse etiology and loss of DNA repair mechanisms also may play a role in allowing
mutations to accumulate. Cancers are also characterized by the ability to invade
surrounding tissues and to metastasize. Many of the molecular alterations involved in this
process have yet to be elucidated.

Gynecologic cancers afflict women of all ages. Cervical cancer is the most common
gynecologic malignancy worldwide, accounting for over 400,000 cases annually. Endometrial
cancer is the most common gynecologic malignancy with approximately 33,000 new cases being
diagnosed annually in American women. Ovarian cancer is the fourth most common cause of
cancer related mortality in American women, with approximately 14,000 deaths occurring from
it in 2000.

The creation of a tissue repository containing tissue specimens, blood/serum, and molecular
extracts (DNA, RNA, protein) will provide a rich source of tissue for future gynecological
disease research studies.

Inclusion Criteria:

- Patients scheduled to undergo surgery for diagnosis and treatment of a gynecologic
disease at one of the participating institutions

- > = 18 years old

- Ability to read English

Exclusion Criteria:

- < 18 years old

Type of Study:


Study Design:

Time Perspective: Prospective

Principal Investigator

LTC G. Larry Maxwell, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Walter Reed Army Medical Center


United States: Federal Government

Study ID:




Start Date:

March 2006

Completion Date:

January 2011

Related Keywords:

  • Endometrial Neoplasms
  • Uterine Cervical Neoplasms
  • Ovarian Neoplasms
  • Leiomyoma
  • Tissue Bank
  • Endometrial neoplasm
  • uterine cervical neoplasm
  • ovarian neoplasm
  • leiomyoma
  • DNA
  • RNA
  • Protein
  • Serum
  • Neoplasms
  • Uterine Cervical Neoplasms
  • Endometrial Neoplasms
  • Genital Diseases, Female
  • Leiomyoma
  • Myofibroma
  • Ovarian Neoplasms
  • Adenoma



University of Pittsburgh Medical Center Pittsburgh, Pennsylvania  15213
Washington Hospital Center Washington, District of Columbia  20010
Duke University Medical Center Durham, North Carolina  27710
The Ohio State University Columbus, Ohio  43210
Gynecologic Disease Center, Walter Reed Army Medical Center Washington, District of Columbia  20307
Wayne State University Kamanos Cancer Institute Detroit, Michigan  48201
Windber Research Institute Windber, Pennsylvania  15963