Inclusion Criteria:

Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both

Criteria

Inclusion Criteria:

4.1 At the time of subject registration, CRAB will verify the institution's IRB date to
ensure that the subject can be enrolled.

4.2 Potential study participants must meet the eligibility criteria found in Section 12.0
(Eligibility Checklist). Candidates will fall into one of four groups:

1. Pancreatic cancer patients;

2. Pancreatic and Liver Disease patients;

3. Healthy, At-Risk Volunteers (smoker, (defined as individuals who have smoked >= 100
cigarettes in their lifetime, and who currently smoke every day or some days [MMWR
November 12, 2004, 53(44);1035-1037]), diabetic, and/or family history); and

4. Healthy Volunteers (no history of cancer). The Eligibility Checklist must be
photocopied, completed and stored on site. Eligibility is confirmed during
registration, by answering yes to the question, Have all eligibility criteria been
met? on the Registration Form.

Eligibility Checklist:

1. Pancreatic Cancer Patient Criteria All subjects, regardless of gender and ethnicity
are eligible for this study Pathological diagnosis of pancreatic malignant neoplasm
Expected availability of clinical follow up data Eighteen years old or older All
subjects must be informed of the investigational nature of this protocol Written,
informed consent obtained in accordance with institutional and federal guidelines

2. Pancreatitis and Liver Disease Subject Criteria All subjects, regardless of gender
and ethnicity are eligible for this study Pathological diagnosis of pancreatitis or
liver disease Eighteen years old or older All subjects must be informed of the
investigational nature of this protocol Written, informed consent obtained in
accordance with institutional and federal guidelines

3. Healthy, At-Risk Volunteers All subjects, regardless of gender and ethnicity are
eligible for this study Is a smoker, is diabetic AND/OR has a family history of
pancreatic cancer Eighteen years old or older with no history of cancer All subjects
must be informed of the investigational nature of this protocol Written, informed
consent obtained in accordance with institutional and federal guidelines

4. Healthy Volunteers (no at-risk factors) All subjects, regardless of gender and
ethnicity are eligible for this study Eighteen years old or older with no history of
cancer All subjects must be informed of the investigational nature of this protocol
Written, informed consent obtained in accordance with institutional and federal
guidelines