Inclusion Criteria:

- histologically documented NSCLC stage I-II

- Complete resection of tumor amd resection margins microscopically tumor free.

- Surgical procedure: According to necessity for oncology radicality a lobectomy,
bilobectomy or pneumectomy will be performed with either radical mediastinal
lymphadenectomy or complete sampling of all relevant lymph node areas.

- Randomization within 60 days after surgical required.

- Initial work-up

- General Conditions: 19-70 years, WHO performance status 0-2, adequate hematological
function, adequate renal and hepatic function, negative pregnancy test.

Exclusion Criteria:

- NSCLC stage II-IV, SCLC or alveolar carcinoma

- Clinical evidence of CNS metastases

- pregnant and lactating patients

- past or concurrent history of malignancies other than NSCLC,except for curatively
treated non melanoma of the skin or in situ cervical carcinoma or other curatively
treated cancer with no evidence of disease for at least five years.

- prior or concurrent antitumor therapy for NSCLC other than surgery.

- Concomitant participation in clinical studies of non-approved experimental agents or
procedures.

- major complications after surgery

- serious concomitant medical conditions

- psychological,familial, sociological or geographical conditions which do not permit
compliance with the study protocol