Randomized Multicenter Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery: Single-Dose Vs. Three Doses of Second-Generation Cephalosporin
Use of prophylactic antibiotics in elective colorectal surgery is essential. Although
single-dose prophylactic antibiotics are recommended, the efficacy of single-dose
cephalosporin without metronidazole and oral antibiotics is not fully proven. We conducted a
multicenter randomized trial of single-dose vs. three doses of the second-generation
cephalosporin, cefmetazole.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Incidence of incisional surgical site infection (SSI)
Shin Fujita, MD. PhD.
Principal Investigator
Japan National Cancer Center Hospital
Japan: Ministry of Health, Labor and Welfare
C000000069
NCT00292708
May 2004
July 2005
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