Quantitative Real Time PCR in Cytolytic Formalin Fixed Breast Cells Obtained by Periareolar Fine Needle Aspiration. An Ancillary Protocol to a Chemoprevention Trial of Letrozole
Phase 1/Phase 2
18 Years
N/A
18 Years
N/A
Not Enrolling
Female
Breast Cancer
Female
Breast Cancer
Trial Information
Quantitative Real Time PCR in Cytolytic Formalin Fixed Breast Cells Obtained by Periareolar Fine Needle Aspiration. An Ancillary Protocol to a Chemoprevention Trial of Letrozole
To assess the quantitative real time PCR results of oligonucleotide probes for a number of
gene transcription products (PCNA, cyclin-D1, ER alpha, PR, pS2, 450 aromatase, bcl-2, bax,
caspase-3, and VEGFR) that may be useful as predictors or indicators of response to
letrozole
Inclusion Criteria:
- evidence of hyperplasia with/without atypia upon random periareolar fine needle
aspiration of breast
- on hormone replacement therapy
- postmenopausal
- increased risk of developing breast cancer based on personal or family history
- never have taken aromatase inhibitors or selective estrogen receptor modulators in
last six months
- women who have a high risk of breast cancer
- older than 18 years
Exclusion Criteria:
- no anticoagulants
- no marked breast tenderness
- not pregnant or within twelve months of breast feeding/childbirth
Type of Study:
Observational
Study Design:
Time Perspective: Prospective
Principal Investigator
Carol J Fabian, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Kansas
Authority:
United States: Institutional Review Board
Study ID:
9298
NCT ID:
NCT00291109
Start Date:
January 2003
Completion Date:
July 2005
Related Keywords:
- Breast Cancer
- breast atypia
- breast epithelial hyperplasia
- Ki-67
- RTPCR
- microdissection
- Breast Neoplasms
Name | Location |
|---|---|
| University of Kansas Medical Center | Kansas City, Kansas 66160-7353 |
