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A Phase II Study of ZD6474 Alone and With Chemotherapy in Advanced NSCLC

Phase 2
18 Years
Not Enrolling
Lung Cancer

Thank you

Trial Information

A Phase II Study of ZD6474 Alone and With Chemotherapy in Advanced NSCLC

ZD6474 is a new investigational drug that is thought to block the formation of new blood
vessels. The growth of new blood vessels is called angiogenesis. Angiogenesis is thought to
be essential for the growth of tumors beyond a small size. It is hoped that ZD6474 will
limit new blood vessel growth in the tumor and "starve" the tumor by limiting blood flow to
it. The second part of this study also includes paclitaxel (Taxol) and carboplatin
(Paraplatin). Both paclitaxel and carboplatin are standard chemotherapy drugs that are
approved by the FDA for use in the treatment of lung cancer.

Before beginning treatment on this study, you will have a biopsy of your tumor. The tissue
taken during this biopsy will be compared with the tissue taken after you receive ZD6474.
The tumor samples will be compared to see what effect ZD6474 has had on tumor cell death.
During the biopsy procedure, you will receive either a local or general anesthetic depending
on the location of your tumor and a small piece of tumor will be removed with a large

Before treatment starts, you will have a complete physical exam by a physician. You will
have routine blood (about 4 teaspoons) and urine tests. Women who are able to have children
must have a negative blood pregnancy test. You will have a chest x-ray and a CT or MRI
scan, a functional MRI, a bone scan if your doctor thinks it is necessary, and a brain scan.
You will also have an ECG (test to measure the electrical activity of the heart) and a ECHO
scan to make sure your heart is healthy enough to receive this treatment.

Treatment on this study will be given in 3-week cycles. During the first three cycles
(i.e., the first 9 weeks) you will take a ZD6474 tablet by mouth each morning on an empty
stomach. While on this study you will receive a physical exam every week. You will also
receive weekly blood tests (about 4 teaspoons) for the first 4 weeks of treatment. After
that you will receive blood tests (about 4 teaspoons) before every 3-week cycle.

After 2 weeks of treatment you will have another biopsy of your tumor, and another
functional MRI. After every 9 weeks of treatment and every 2 cycles thereafter you will
have a repeat CT or MRI to evaluate your tumor. If your disease has responded to ZD6474 or
stayed the same, you will go on to the second part of this study. If your disease has
gotten worse or intolerable side effects occur, you will be taken off this study and your
doctor will discuss treatment options with you.

If you continue on to the second part of this study, you will be randomly assigned (as in
the toss of a coin) to receive either: a) daily ZD6474 alone, or b) paclitaxel and
carboplatin every 3 weeks along with daily ZD6474. You have an equal chance of being
assigned to either group. If you receive paclitaxel, you will receive it as a 3-hour
infusion into a vein on the first day of each treatment cycle. If you receive carboplatin,
you will receive it by vein immediately following the paclitaxel infusion. The carboplatin
infusion will take between 15 and 30 minutes. Treatment with either daily ZD6474 or ZD6474
plus paclitaxel and carboplatin will continue until your diseases worsens or until severe
side effects occur.

This is an investigational study. ZD6474 is an investigational drug that has been approved
by the FDA for research use only. A total of up to 120 patients will take part in this
study. All will be enrolled at M. D. Anderson.

Inclusion Criteria:

1. An informed consent form must be completed before any protocol specific screening.
Patient must consent to a tissue biopsy at study entry and again at the week 3.

2. Patients must have a diagnosis of stage IIIb or stage IV non-small cell lung cancer
(histologically or cytologically proven) and must not be eligible for combined
chemotherapy and radiation therapy.

3. Patients must have at least one site of measureable disease that is amenable to
biopsy. The patient must not have had radiation to this site. Lesion must be at least
20 mm in the longest diameter by spiral CT or 20 mm with conventional techniques
according to RECIST.

4. Eligible patients must have an ECOG performance status of 0-1.

5. Patients must have adequate hepatic, renal, and bone marrow function as defined
below: 1) Serum creatinine < 1.5 mg/dL or a calculated creatinine clearance > 60
mL/min 2)· Total bilirubin < 1.5 x ULN ·3) ALT or AST 5.0 x ULN if related to liver metastases OR Alk Phos
3,000/mm**3 ·5) ANC > 1,500 mm**3 ·6) Platelets > 100,000/mm**3 ·7) Hemoglobin > 10
g/dL ·8) PT/PTT < 1.5 x normal

6. Patients must be >= 18 years of age.

Exclusion Criteria:

1. Patients are excluded if they have received prior chemotherapy for this disease type.

2. Patients with brain metastases are not eligible for this study unless treated at
least 4 weeks before entry and stable without steroid treatment for 1 week.

3. Prior radiation therapy allowed to <25% of the bone marrow. Prior radiation to the
whole pelvis is not allowed. Prior radiotherapy must be completed at least 4 weeks
before study enrollment. Patients must have recovered from the acute toxic effects of
the treatment prior to study enrollment.

4. Patients may not have any concomitant uncontrolled medical or psychiatric disorders.

5. Patients must not be pregnant or breast-feeding. All women of childbearing potential
must have a negative pregnancy test. Childbearing potential will be defined as women
who have had menses within the past 12 months, who have not had tubal ligation or
bilateral oophorectomy. There is no specific information available on the effects of
this drug on women who are pregnant or breast-feeding. Therefore these patients are
excluded from this study because of the unknown risks involved. All sexually active
patients must practice adequate contraception for the entire treatment period.

6. Patients must not have undergone minor surgery (e.g., central venous catheter
placement) within 24 hours of treatment with ZD6474. Patients may not have undergone
any major surgery (e.g., laparotomy, thoracotomy, or craniotomy) within four weeks of

7. Patients may not have a history of a bleeding diathesis.

8. Patients must agree not to use herbal remedies or other over-the-counter biologics
(e.g., shark cartilage)

9. Significant cardiac event (including symptomatic heart failure or angina) within 3
months of entry or presence of cardiac disease that in the opinion of the
Investigator increase the risk of ventricular arrythmia.

10. History of clinically significant arrhythmia (multifocal PVCs, bigeminy, trigeminy,
ventricular tachycardia) which is symptomatic or requires treatment (CTC grade 3) or
asymptomatic sustained ventricular tachycardia. Atrial fibrillation, controlled on
medication is not excluded.

11. Presence of left bundle branch block (LBBB).

12. Previous history of QT prolongation as a result from other medication that required
discontinuation of that medication.

13. Congenital long QT syndrome or 1st degree relative with unexplained sudden death
under 40 years of age.

14. QTc with Bazett's correction that is unmeasurable, or >/= 480 msec on screening ECG.
If a patient has QTc >/= 480 msec on screening ECG, the screening may be repeated
twice (at least 24 hours apart). The average QTc from the 3 screening ECGs must be <
480 msec in order for the patient to be eligible for the study.

15. Any concomitant medications that may cause QTc prolongation or induce Torsades de
Pointes (see Appendix F) or induce CYP3A4 function (see section 8.2).

16. Potassium level less than 3.5 meq/l; calcium and magnesium level outside normal
limits. Supplementation of electrolytes is permitted.

17. Left ventricular ejection fraction less than 45% measured by echocardiogram for
subjects with previous anthracycline therapy (total dose greater than 450 mg/m2),
significant cardiovascular disease, or chest irradiation

18. History of severe hypersensitivity reaction to drugs formulated with polysorbate 80

19. Any concurrent condition which in the investigator's opinion makes it undesirable for
the subject to participate in the trial or which would jeopardize compliance with the

20. Participation in an investigational trial within the past 30 days.

21. Because of DCE-MRI, individuals with the following are excluded: 1) Cardiac
pacemakers or neurostimulators, 2) Metal implants other than those approved as being
safe in an MRI environment, 3) Claustrophobia, 4) Physical characteristics that
preclude a MRI scan

22. Hypertension not controlled by medical therapy (systolic blood pressure greater than
160 mm Hg or diastolic blood pressure greater than 100 mm Hg)

23. Currently active diarrhea that may affect the ability of the patient to absorb the
ZD6474 or tolerate diarrhea.

24. Previous or current malignancies at other sites within the last 5 years, with the
exception of cervical carcinoma in situ and adequately treated basal cell carcinoma
or squamous cell carcinoma of the skin.

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Response Rate

Outcome Time Frame:

Radiologic evaluations performed after weeks 2 and 9 of treatment, then every 2 cycles or as indicated if progressive disease is suspected.

Safety Issue:


Principal Investigator

Vassiliki Papadimitrakopoulou, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

M.D. Anderson Cancer Center


United States: Food and Drug Administration

Study ID:




Start Date:

January 2006

Completion Date:

April 2008

Related Keywords:

  • Lung Cancer
  • Non-Small Cell Lung Cancer
  • Lung Cancer
  • Carboplatin
  • Paclitaxel
  • ZD6474
  • Lung Neoplasms



University of Texas M.D.Anderson Cancer Center Houston, Texas  77030