Inclusion Criteria:

- Patients undergoing radiotherapy or chemoradiotherapy for histologically confirmed
squamous cell carcinoma of oral cavity or oropharynx (1.8-2.0 Gy/day; 5 days per
week, totally 59.4-70 Gy).

- Normal mucosa at baseline (i.e. Common Toxicity Criteria (CTC) grade 0)

- >= 18 years of age

- Women of childbearing potential must use an adequate contraceptive method and have a
negative pregnancy test

- Written informed consent

Exclusion Criteria:

- Patients who will receive hyperfractionated or accelerated radiotherapy

- History of malignancies within the past five years other than non-melanomatous skin
cancers (with the exception of squamous cell carcinoma of the skin) or carcinoma in
situ of the cervix

- Previous neoplasm in the head and neck area, whether malignant or not

- Previous radiation therapy for head and neck cancer

- If wound from curative surgery have not healed

- Patients expected to receive agents that would interfere with the investigator's
ability to assess changes in the appearance of the mucositis during the study

- Use of radiosensitizers

- History or clinical evidence of active significant acute or chronic diseases that may
compromise the ability to evaluate or interpret the effects of the study treatment on
mucositis

- Evidence of distant metastatic disease

- Expected survival of less than 12 months

- > grade 3 performance status (WHO grading)

- Granulocyte count < 2.000/mm3 and platelet count < 100,000/mm3

- Serum creatinine >= 150 micromol/L

- Total bilirubin >= 36 micromol/L, AST > 3 times the upper normal limit

- Any subject who, in the opinion of the investigator, is unlikely to comply with the
study procedures, or is unlikely to complete the study due to different reasons like
e.g. language barriers or mental incapacity

- Participation in a clinical trial in the last 30 days Receipt of any investigational
product within 30 days prior to this trial