Trial Information

Familial Barrett's Esophagus

This research study is trying to determine whether Barrett's esophagus and associated
esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain
families. Persons who are affected with Barrett's esophagus or esophageal cancer
(adenocarcinoma type) are asked to complete a questionnaire that determines their habits and
asks a detailed family history. Family members of patients seen at University Hospitals of
Cleveland and the Cleveland Clinic are also being recruited for screening tests of their
esophagus. The investigators plan to eventually screen family members at all participating
institutions. This research will eventually lead to the identification of inherited genetic
changes that cause Barrett's esophagus and esophageal cancer. It will help the
investigators develop better methods for preventing or identifying esophageal cancer at an
early curable stage.