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Familial Barrett's Esophagus

18 Years
Open (Enrolling)
Barrett's Esophagus, Esophageal Neoplasm

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Trial Information

Familial Barrett's Esophagus

This research study is trying to determine whether Barrett's esophagus and associated
esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain
families. Persons who are affected with Barrett's esophagus or esophageal cancer
(adenocarcinoma type) are asked to complete a questionnaire that determines their habits and
asks a detailed family history. Family members of patients seen at University Hospitals of
Cleveland and the Cleveland Clinic are also being recruited for screening tests of their
esophagus. The investigators plan to eventually screen family members at all participating
institutions. This research will eventually lead to the identification of inherited genetic
changes that cause Barrett's esophagus and esophageal cancer. It will help the
investigators develop better methods for preventing or identifying esophageal cancer at an
early curable stage.

Inclusion Criteria

Eligible cases will be defined as those patients and their family members who meet the
following criteria:

- Barrett's esophagus confirmed by review of pathology and endoscopy report or
adenocarcinoma of the esophagus or family members of person with Barrett's esophagus
or adenocarcinoma of the esophagus.

- Male or female age 18 or older at time of enrollment or male or female less than 18
years of age at time of enrollment with parental consent.

- Ability to give informed consent, if patient is age 18 or older.

Type of Study:


Study Design:

Observational Model: Family-Based, Time Perspective: Cross-Sectional

Principal Investigator

Amitabh Chak, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Hospitals of Cleveland, CWRU, Cleveland, OH


United States: Federal Government

Study ID:




Start Date:

October 2005

Completion Date:

September 2017

Related Keywords:

  • Barrett's Esophagus
  • Esophageal Neoplasm
  • Barrett's Esophagus
  • Barrett Esophagus
  • Neoplasms
  • Esophageal Diseases
  • Esophageal Neoplasms



Mayo Clinic Rochester, Minnesota  55905
Washington University School of Medicine Saint Louis, Missouri  63110
University Hospitals of Cleveland Cleveland, Ohio  44106
Creighton University Medical Center Omaha, Nebraska  68131-2197
University of Pennsylvania Philadelphia, Pennsylvania  19104
The Cleveland Clinic Cleveland, Ohio  44195
Columbia University Medical Center New York, New York  10032
University of North Carolina at Chapel Hill Chapel Hill, North Carolina  27599
Johns Hopkins Hospital Baltimore, Maryland  21287
Northeastern Ohio University College of Medicine, Mercy Medical Center Canton, Ohio  44718
Cleveland Veterans Administration Medical Center - Wade Park Cleveland, Ohio  44106
Fred Hutchinson Cancer Research Center, UWMC Seattle, Washington  98109