Inclusion Criteria:

- Patients must have histologically-confirmed advanced CRC that has progressed through
an irinotecan-containing regimen for metastatic disease, or has recurred during, or
within 6 months of completing, an irinotecan-containing adjuvant regimen, or other
histologically-confirmed solid tumors refractory to standard therapy.

- Age at least 18 years at the time of the first dose of study drug.

- Both males and females are eligible. Sexually active females, unless surgically
sterile (or at least one year post-menopausal), must have used an effective method of
avoiding pregnancy (including oral or implanted contraceptives, IUD, female condom,
diaphragm with spermicide, cervical cap, abstinence, use of a condom by the sexual
partner or sterile sexual partner) for 30 days prior to the first dose of study drug,
and must agree to continue using such precautions for 30 days after the final dose of
study drug. Sexually active females of reproductive potential must have a negative
serum b human chorionic gonadotropin (bhCG) pregnancy test within 3 days of start of
therapy.

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. ECOG criteria
are described in Appendix A.

- Patients who had prior treatment with chemotherapy or radiotherapy or had prior
surgery are eligible for study entry if at least 4 weeks have past since their
treatment/surgery.

- All toxicities related to prior treatment must have resolved and all surgical wounds
must have healed.

- Prior immunotherapy with approved agents is allowable.

- ANC ³1500/mm3, platelets ³100,000/mm3, hemoglobin >10.0 g/dL, serum creatinine £1.5
mg/dL or calculated creatinine clearance >50 mL/min, serum bilirubin £2.0 mg/dL, and
AST/ALT £5 times the upper limit of normal (ULN).

- PT/PTT less than ULN or international normalized ratio (INR) less than 1.12.

- Thyroxine (T4) and thyroid-stimulating hormone (TSH) within normal limits.

- Written informed consent obtained from the patient prior to receipt of any study
medication or beginning study procedures.

Exclusion Criteria:

- Pregnancy or nursing.

- Known brain metastases or primary brain tumors, symptomatic pleural effusion or
ascites requiring paracentesis.

- Respiratory insufficiency requiring oxygen treatment, or lymphangitic involvement of
lungs.

- Any evidence of hematemesis, melena, hematochezia, or gross hematuria.

- A history of significant adverse events related to a previously administered
humanized monoclonal antibody.

- A known human immunodeficiency virus (HIV) or hepatitis virus infection.

- A prior myocardial infarction or angina, or uncontrolled hypertension (systolic blood
pressure >150 mm Hg).

- A prior stroke or transient ischemic attack.

- An active infection requiring systemic antiinfective therapy.

- Received an investigational agent in the last 4 weeks of initiation of study
treatment.

- A requirement for palliative chemotherapy, hormonal therapy, or immunotherapy during
the course of the study.

- Clinical evidence of bowel obstruction.

- A history of other malignancies within the past 5 years (with the exception of basal
cell carcinoma of the skin or completely excised in situ carcinoma of the cervix).

- A general medical or psychological condition or behavior, including substance
dependence or abuse that, in the opinion of the investigator, might not permit the
patient to complete the study or sign the informed consent.

- Prior treatment with MEDI-522 or MEDI-523.