Inclusion Criteria:

1. Subjects 18 years of age or older.

2. Subjects with histologically or cytologically confirmed NSCLC that is considered
generally unresectable or inoperable. No prior chemotherapy for NSCLC or thoracic
radiotherapy is allowed.

3. Subjects with Stage IIIA or IIIB disease (clinically or surgically staged).

4. Subject with disease designated T3, N0-N1 based on mediastinal invasion or proximity
to the carina.

Subjects with contralateral mediastinal disease (N3) are eligible if all gross
disease can be encompassed within the radiation port.

5. Subjects with pleural fluid that is a transudate and is cytologically negative.

6. Subjects with pleural effusions that are seen only on CT scan and are too small to
tap.

7. Subjects with measurable or evaluable disease.

8. Subjects with PS of 0 or 1 by the ECOG scale (see Appendix 2).

9. Subjects with laboratory values as follows:

Absolute granulocyte count: ≥1,500/µL Platelets: ≥100,000/µL Total bilirubin: ≤1.5 x
institutional upper normal limit Serum creatinine: <1.6 mg/dL or Creatinine
clearance:>40 mL/min

AST and ALT: ≤2.5 x institutional upper normal limit FEV 1 >800 cc

10. Subjects must be nonpregnant and non-lactating. Subjects of childbearing potential
must implement an effective method of contraception during the study. All female
subjects, except those who are postmenopausal or surgically sterilized, must have a
negative pre-study serum or urine pregnancy test.

11. Subjects must have a life expectancy > 2 months.

12. Subjects must be seen by both a medical oncologist and a radiation oncologist before
registration.

13. Subjects must be informed of the investigational nature of the study and must sign an
informed consent form.

Exclusion Criteria:

1. Subjects with disease designated T3, N0-N1 based on chest wall invasion, subjects
with N3 supraclavicular disease, or subjects with superior sulcus tumors.

2. Subjects with cytologically positive pleural effusions.

3. Subjects who have received prior chemotherapy or radiochemotherapy for lung cancer or
prior chest radiotherapy.

4. Subjects who are < 3 weeks since formal exploratory thoracotomy.

5. Subjects with a history of other cancers except in situ carcinoma of the cervix or
breast, inactive nonmelanomatous skin cancer, or other cancer, unless the subject has
been free of disease for > 5 years.

Also, exceptions can be made by the PI for a subject with a malignancy for which the
prognosis is substantially better than the subject's prognosis for NSCLC.

6. Subjects with an active serious infection or other serious underlying medical
condition that would otherwise impair their ability to receive protocol treatment.
Subjects with post-obstructive pneumonia remain eligible.

7. Subjects with dementia or significantly altered mental status that would prohibit the
understanding and/or giving of informed consent.

8. Pregnant or breast-feeding females or subjects not using adequate methods of birth
control.

9. Subjects receiving other investigational therapy or non-approved therapy within 30
days before Day 1 of protocol treatment.

10. Subjects with known hypersensitivity to E coli-derived proteins, pegfilgrastim, or
any component of the product will be excluded.

11. Subjects with metastatic disease are excluded.

12. Subjects taking phenytoin, rifampicin, barbiturates, carbamazepine, or St. John's
Wort.

13. Any evidence of clinically active ILD (subjects with chronic stable radiographic
changes who are asymptomatic need not be excluded).

14. Subjects with evidence of any other significant clinical disorder or laboratory
finding that makes it undesirable for the subject to participate in the trial.

15. As judged by the investigator, subjects with any evidence of severe or uncontrolled
systemic disease (eg, unstable or uncompensated respiratory, cardiac, hepatic, or
renal disease).

16. Subjects with known severe hypersensitivity to ZD1839 or any of the excipients of
this product.