A Pilot Study of MR-Guided High Dose Rate Brachytherapy With MR Image Acquisition for Patients With Cervical Cancer
- Determine the feasibility of magnetic resonance-guided, endocavitary, high-dose rate
brachytherapy implants in patients with stage IB-IVB cervical cancer.
- Provide more reliable dose-volume estimations based on three-dimensional imaging-based
treatment planning in patients treated with this regimen.
- Determine the toxic effects and treatment tolerance in patients treated with this
- Correlate three-dimensional dose-volume histograms of organs at risk with treatment
toxicity in patients treated with this regimen.
- Determine the disease status, time and patterns of relapse, and survival of patients
treated with this regimen.
OUTLINE: Patients undergo external beam radiotherapy 4-5 days a week for up to 7 weeks.
Patients also undergo MRI-guided high-dose brachytherapy comprising one brachytherapy
implant a week for 3-6 implants. Brachytherapy may be administered during or after external
After completion of study treatment, patients are followed periodically for 5 years.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.
Primary Purpose: Treatment
Shervin Karimpour, MD
NCI - Radiation Oncology Branch; ROB
United States: Federal Government
|Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support||Bethesda, Maryland 20892-1182|