Inclusion Criteria

DISEASE CHARACTERISTICS:

- Radiological or established histological diagnosis of glioma

- WHO grade 2-4 disease

- Presence of a new or enlarging enhancing lesion on gadolinium-enhanced MRI after
prior radiotherapy

- Differentiation of recurrent tumor from radiation necrosis is not possible

- No clinically significant signs of uncal herniation, including any of the following:

- Acute pupillary enlargement

- Rapidly developing (i.e., over hours) motor changes

- Rapidly decreasing level of consciousness

PATIENT CHARACTERISTICS:

- Platelet count ≥ 75,000/mm^3

- WBC ≥ 3,000/mm^3

- Gamma-glutamyl-transferase ≤ 5 times upper limit of normal (ULN)

- Absolute neutrophil count ≥ 1,500/mm^3

- Hemoglobin ≥ 10 g/dL

- SGOT and SGPT ≤ 2 times ULN

- Alkaline phosphatase ≤ 2 times ULN

- Lactic dehydrogenase ≤ 2 times ULN

- Direct and total bilirubin normal

- Amylase normal

- Haptoglobin normal

- Serum electrolytes normal

- CBC with platelets normal

- PT, PTT normal

- BUN and creatinine normal

- Not pregnant or lactating

- Urinalysis normal

- Negative pregnancy test

- Female patients must be postmenopausal for ≥ 1 year or surgically sterile, or on 1 of
the following methods of birth control for ≥ 1 month: IUD, oral contraceptives,
Depo-Provera, or Norplant

- These criteria can be waived at the discretion of the investigator if the
patient's intracranial tumor is considered life threatening and the 1-month wait
required is not in the best interest of the patient

- No known allergic or hypersensitivity reactions to previously administered
radiopharmaceuticals

- No known HIV positivity

- Not requiring monitored anesthesia for positron emission tomography scanning

PRIOR CONCURRENT THERAPY:

- Concurrent biopsy or neurosurgical procedure for diagnostic and/or therapeutic
purposes for this cancer allowed

- Concurrent surgery for this cancer allowed