Phase 1/2 Study of Cord Blood Transplantation From Unrelated Donor for Adult Patients With Hematologic Malignancies Using Myeloablative Conditioning Regimen
Although cord blood is considered as an alternative donor source for allogeneic
hematopoietic stem cell transplantation, its procedure has yet to be standardized. Recently,
a single institute result of cord blood transplantation for adult patients with hematologic
malignancies have been reported by Takahashi et al (Blood 2004:104;3813-3820), in which the
survival was significantly better than that of bone marrow transplantation from unrelated
donor. The purpose of this study was to reevaluate the safety and efficacy of cord blood
transplantation for adult patients with hematologic malignancies using the same transplant
procedures in a multi-institutional setting.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Non-relapse mortality at 1 year
Hisashi Sakamaki, M.D., Ph.D.
Tokyo Metropolitan Komagome Hospital
Japan: Institutional Review Board