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Molecular Genetic and Pathological Studies of Anal Tumors

18 Years
Open (Enrolling)
Rectal Cancer, Colon Cancer, Colonic Neoplasms, Anal Cancer

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Trial Information

Molecular Genetic and Pathological Studies of Anal Tumors

To determine the status of previously identified anal cancer molecular markers and any
correlations with outcome as well as to discover new molecular biomarkers through
correlating molecular data with clinical outcome. Study of tissue samples and cells from
biopsies of your lesion and blood sample. We hope to learn the role genes and proteins may
play in the development of anal cancer. Experiments will be performed using this tissue and
blood, include analysis of DNA, analysis of RNA expression levels, analysis of protein
levels of important gene products, and development of tissue culture cell lines.

Inclusion Criteria:

Inclusion Criteria:

- Patients with anal tumors

- Undergoing surgery for elective colon and rectal surgery

Exclusion Criteria:No other patients other than adult patients with anal cancer or high
risk for anal cancer refered to Stanford will be enrolled to the study. No Children will
be included to the study

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Genetic analysis of blood sample as well as tissues , will provide us with any possible tumor marker for a better prognostic indicator.

Outcome Time Frame:

Annual assessment.

Safety Issue:


Principal Investigator

Mark Lane Welton

Investigator Role:

Principal Investigator

Investigator Affiliation:

Stanford University


United States: Institutional Review Board

Study ID:




Start Date:

September 2004

Completion Date:

December 2013

Related Keywords:

  • Rectal Cancer
  • Colon Cancer
  • Colonic Neoplasms
  • Anal Cancer
  • Anus Neoplasms
  • Neoplasms
  • Colonic Neoplasms
  • Rectal Neoplasms



Stanford University School of Medicine Stanford, California  94305-5317