Trial Information

The University of Louisville Ovarian Screening Study

In the year 2001 approximately 23,400 women in the USA are expected to be diagnosed with
ovarian carcinoma and 13,900 will die of the disease. This means that within the USA more
women die annually from ovarian cancer than all other gynecologic malignancies combined.
Within the Commonwealth of Kentucky approximately 250 women per year develop ovarian
carcinoma.

Survival for patients with ovarian cancer is directly related to the stage of disease at
diagnosis. Unfortunately, the majority of women present with advanced disease (Stage
III and IV) and most of these patients will die of the disease.

The aim of screening for ovarian cancer is to reduce the morbidity and mortality by
detecting the disease at an early stage since ovarian cancer detected when disease is
confined to the ovary (Stage I) is associated with a dramatically improved 5-year survival.
Disease confined to the ovary may be cured in over 90% of patients, in some cases without
the need for chemotherapy.