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A Phase III Trial of Carboplatin and Paclitaxel Plus Placebo Versus Carboplatin and Paclitaxel Plus Concurrent Bevacizumab (NSC # 704865, IND #7921) Followed By Placebo, Versus Carboplatin and Paclitaxel Plus Concurrent and Extended Bevacizumab, in Women With Newly Diagnosed, Previously Untreated, Suboptimal Advanced Stage Epithelial Ovarian, Primary Peritoneal Cancer, or Fallopian Tube Cancer

Phase 3
18 Years
Open (Enrolling)
Brenner Tumor, Fallopian Tube Cancer, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Mixed Epithelial Carcinoma, Ovarian Mucinous Cystadenocarcinoma, Ovarian Serous Cystadenocarcinoma, Ovarian Undifferentiated Adenocarcinoma, Primary Peritoneal Cavity Cancer, Stage III Ovarian Epithelial Cancer, Stage IV Ovarian Epithelial Cancer

Thank you

Trial Information

A Phase III Trial of Carboplatin and Paclitaxel Plus Placebo Versus Carboplatin and Paclitaxel Plus Concurrent Bevacizumab (NSC # 704865, IND #7921) Followed By Placebo, Versus Carboplatin and Paclitaxel Plus Concurrent and Extended Bevacizumab, in Women With Newly Diagnosed, Previously Untreated, Suboptimal Advanced Stage Epithelial Ovarian, Primary Peritoneal Cancer, or Fallopian Tube Cancer


I. Compare the overall survival of patients with stage III or stage IV ovarian epithelial,
primary peritoneal cancer, or fallopian tube cancer treated with carboplatin and paclitaxel
vs carboplatin, paclitaxel, and concurrent bevacizumab with vs without extended bevacizumab.


I. Compare the duration of progression-free survival of patients treated with these

II. Compare the incidence of severe toxicity of these regimens in these patients.

III. Compare the quality of life of patients treated with these regimens.


I. Determine the relationship between angiogenic markers and clinical outcome (tumor
response, progression-free survival, and overall survival) in patients treated with these

II. Determine the predictive value of a set of genes whose expression correlates with
survival of these patients.

III. Bank whole blood for research. IV. Determine if genetic variations in genes associated
with essential hypertension including WNK lysine deficient protein kinase 1 (WNK1), G
protein-coupled receptor kinase 4 (GRK4), and kallikrein B (KLKB1) predict which patients
are likely to develop bevacizumab-induced hypertension.

OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients
are stratified according to stage of disease (III vs IV) or initial performance status (0 vs
1 vs 2). Patients are randomized to 1 of 3 treatment arms.

ARM I: Patients receive paclitaxel IV over 3 hours and carboplatin IV over 30 minutes on day
1. Beginning in course 2, patients also receive placebo IV over 30-90 minutes on day 1.
Treatment repeats every 21 days for 6 courses. Beginning in course 7, patients receive
placebo alone IV over 30-90 minutes on day 1. Treatment with placebo repeats every 21 days
for up to 22 courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive paclitaxel and carboplatin as in arm I. Beginning in course 2,
patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21
days for 6 courses. Beginning in course 7, patients receive placebo alone IV over 30-90
minutes on day 1. Treatment with placebo repeats every 21 days for up to 22 courses in the
absence of disease progression or unacceptable toxicity.

ARM III: Patients receive paclitaxel and carboplatin as in arm I. Beginning in course 2,
patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21
days for 6 courses. Beginning in course 7, patients receive bevacizumab alone IV over 30-90
minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 22 courses in
the absence of disease progression or unacceptable toxicity.

Quality of life is assessed at baseline, before courses 4, 7, 13, and 21, and then at 6
months after study completion. After completion of study treatment, patients are followed
periodically for at least 5 years.

Inclusion Criteria:

- Histologically confirmed ovarian epithelial, primary peritoneal*, or fallopian tube

- Stage III with any gross (macroscopic or palpable) residual disease OR stage IV

- The following histologic epithelial cell types are allowed provided the histologic
features of the tumor are compatible with a primary müllerian epithelial

- Serous adenocarcinoma

- Endometrioid adenocarcinoma

- Mucinous adenocarcinoma

- Undifferentiated carcinoma

- Clear cell adenocarcinoma

- Mixed epithelial carcinoma

- Transitional cell carcinoma

- Malignant Brenner tumor

- Adenocarcinoma not otherwise specified

- No borderline ovarian epithelial tumor (formerly "tumors of low malignant potential")

- Prior diagnosis of a borderline tumor that was surgically resected and an
unrelated, new, invasive ovarian epithelial or primary peritoneal cancer that
subsequently develops is allowed provided there was no prior chemotherapy for
any ovarian tumor

- No recurrent invasive ovarian epithelial cancer treated with surgery only (e.g.,
stage IA or IB low-grade epithelial ovarian or fallopian tube cancer)

- No synchronous primary endometrial cancer or prior primary endometrial cancer unless
all of the following criteria are met:

- Stage ≤ IB

- Superficial myometrial invasion without vascular or lymphatic invasion

- No poorly differentiated subtypes (i.e., papillary serous, clear cell, or other
FIGO grade 3 lesions)

- Must have undergone surgery for ovarian epithelial, primary peritoneal, or fallopian
tube cancer in the past 1-12 weeks AND have tissue available for histologic

- Patients with stage III disease in which the largest maximal diameter of any
residual tumor implant a the completion of initial surgery is ≤ 1 cm will be
defined as "optimal" (all others will be defined as "suboptimal")

- Measurable or nonmeasurable disease

- No tumor involving active major vessels

- No prior or concurrent CNS disease, including primary brain tumor or brain metastases

- Performance status - GOG 0-2

- Absolute neutrophil count ≥ 1,500/mm^3 without induction or support by granulocyte
colony stimulating factors

- Platelet count ≥ 100,000/mm^3

- No active bleeding

- No known bleeding disorder or coagulopathy

- Bilirubin ≤ 1.5 times upper limit of normal (ULN)

- SGOT ≤ 2.5 times ULN

- Alkaline phosphatase ≤ 2.5 times ULN

- INR ≤ 1.5 (2-3 with stable-dose therapeutic warfarin for management of venous
thrombosis including pulmonary thromboembolus)

- PTT < 1.2 times ULN

- No acute hepatitis

- Creatinine ≤ 1.5 times ULN

- Urine protein:creatinine ratio < 1.0

- Urine protein < 1 g/24-hr urine collection

- No New York Heart Association class II-IV congestive heart failure

- No myocardial infarction or unstable angina within the past 6 months

- No uncontrolled hypertension (i.e., blood pressure > 150/90 mm Hg)

- No serious cardiac arrhythmia requiring medication except for patients with
asymptomatic atrial fibrillation with a controlled ventricular rate

- No other clinically significant cardiovascular disease

- No clinically significant peripheral vascular disease ≥ grade 2

- No history of cerebral vascular accident, transient ischemic attack, or subarachnoid
hemorrhage within the past 6 months

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 6 months after
completion of study treatment

- No neuropathy (sensory and motor) > grade 1

- No known hypersensitivity to Chinese hamster ovary cell products or recombinant human
or humanized antibodies

- No other malignancy within the past 5 years except nonmelanoma skin cancer

- No active infection that requires parenteral antibiotics

- No serious nonhealing wound, ulcer, or bone fracture

- No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess within the past 28 days

- Granulating incisions healing by secondary intention with no evidence of fascial
dehiscence or infection are allowed

- No other pathological condition that would confer a high risk of bleeding

- No uncontrolled seizures

- No significant traumatic injury within the past 4 weeks

- No clinical symptoms or signs of gastrointestinal obstruction that require parenteral
hydration and/or nutrition

- No other medical history or condition that, in the opinion of the investigator, would
preclude study participation

- No prior targeted therapy for ovarian epithelial or peritoneal primary cancer,
including, but not limited to, any of the following:

- Vaccines

- Antibodies

- Tyrosine kinase inhibitors

- No prior bevacizumab

- No other prior antivascular endothelial growth factors (VEGF)

- No other concurrent biologic therapy

- No other concurrent cytotoxic or anticancer therapy

- No prior chemotherapy for abdominal or pelvic tumor including neoadjuvant
chemotherapy for their ovarian or primary peritoneal cancer

- More than 3 years since prior adjuvant chemotherapy for localized breast cancer AND
patient remains free of recurrent or metastatic disease

- No other concurrent chemotherapy

- Ovarian estrogen with or without progestin replacement therapy as indicated at the
lowest effective dose(s) for control of menopausal symptoms at any time allowed

- No progestins for management of anorexia while on study-directed therapy or
prior to disease progression

- No prior hormonal therapy for ovarian, peritoneal primary, or fallopian tube cancer

- No concurrent hormonal therapy

- More than 3 years since prior radiotherapy for localized cancer of the breast, head
and neck, or skin AND patient remains free of recurrent or metastatic disease

- No prior radiotherapy to the abdominal cavity or pelvis

- No concurrent radiotherapy

- No concurrent amifostine or other protective reagents

- At least 4 weeks since prior major surgical procedure or open biopsy

- At least 1 week since prior core biopsy

- No concurrent major surgery including abdominal surgery (laparotomy or laparoscopy)
prior to disease progression (e.g., colostomy or enterostomy reversal, interval or
secondary cytoreductive surgery, or second look surgery

- No prior cancer therapy that would preclude study treatment

- No concurrent consolidation or maintenance therapy

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

Progression-free survival measured by Response Evaluation Criteria in Solid Tumors (RECIST)

Outcome Time Frame:

From study entry until disease progression, death or date of last contact, up to 5 years

Safety Issue:


Principal Investigator

Robert Burger

Investigator Role:

Principal Investigator

Investigator Affiliation:

Gynecologic Oncology Group


United States: Food and Drug Administration

Study ID:




Start Date:

September 2005

Completion Date:

Related Keywords:

  • Brenner Tumor
  • Fallopian Tube Cancer
  • Ovarian Clear Cell Cystadenocarcinoma
  • Ovarian Endometrioid Adenocarcinoma
  • Ovarian Mixed Epithelial Carcinoma
  • Ovarian Mucinous Cystadenocarcinoma
  • Ovarian Serous Cystadenocarcinoma
  • Ovarian Undifferentiated Adenocarcinoma
  • Primary Peritoneal Cavity Cancer
  • Stage III Ovarian Epithelial Cancer
  • Stage IV Ovarian Epithelial Cancer
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Brenner Tumor
  • Carcinoma
  • Cystadenocarcinoma
  • Peritoneal Neoplasms
  • Fallopian Tube Neoplasms
  • Carcinoma, Endometrioid
  • Cystadenocarcinoma, Mucinous
  • Cystadenocarcinoma, Serous
  • Neoplasms, Glandular and Epithelial
  • Ovarian Neoplasms



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Kaiser Permanente-South San FranciscoSouth San Francisco, California  94080
Kaiser Permanente-StocktonStockton, California  95210
Kaiser Permanente-VallejoVallejo, California  94589
Kaiser Permanente-Walnut CreekWalnut Creek, California  94596
The Medical Center of AuroraAurora, Colorado  80012
Penrose-Saint Francis HealthcareColorado Springs, Colorado  80907
Memorial Hospital Colorado SpringsColorado Springs, Colorado  80909
Saint Anthony Central HospitalDenver, Colorado  80204
Exempla Saint Joseph HospitalDenver, Colorado  80218
Colorado Cancer Research Program CCOPDenver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical CenterGrand Junction, Colorado  81502
Saint Mary Corwin Medical CenterPueblo, Colorado  81004
Saint Francis Hospital and Medical CenterHartford, Connecticut  06105
The Hospital of Central ConnecticutNew Britain, Connecticut  06050
Stamford HospitalStamford, Connecticut  06904
M D Anderson Cancer Center- OrlandoOrlando, Florida  32806
Palm Beach Cancer Institute-Main OfficeWest Palm Beach, Florida  33401
Phoebe Putney Memorial HospitalAlbany, Georgia  31703
Oncare Hawaii Inc-POB IIHonolulu, Hawaii  96813
Oncare Hawaii Inc-KuakiniHonolulu, Hawaii  96817
University of HawaiiHonolulu, Hawaii  96813
Pacific Cancer Institute of MauiWailuku, Hawaii  96793
Saint Luke's Mountain States Tumor InstituteBoise, Idaho  83712
Saint Anthony's HealthAlton, Illinois  62002
Rush - Copley Medical CenterAurora, Illinois  60504
Resurrection HealthcareChicago, Illinois  60631
Saint Francis HospitalEvanston, Illinois  60202
Evanston CCOP-NorthShore University HealthSystemEvanston, Illinois  60201
Hopedale Medical Complex - HospitalHopedale, Illinois  61747
Joliet Oncology-Hematology Associates LimitedJoliet, Illinois  60435
Stoffel, Thomas J MD (UIA Investigator)Moline, Illinois  61265
Garneau, Stewart C MD (UIA Investigator)Moline, Illinois  61265
Sharis, Christine M MD (UIA Investigator)Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator)Moline, Illinois  61265
Good Samaritan Regional Medical CenterMt. Vernon, Illinois  62864
Community Cancer Center FoundationNormal, Illinois  61761
Illinois CancerCare-Ottawa ClinicOttawa, Illinois  61350
Ottawa Regional Hospital and Healthcare CenterOttawa, Illinois  61350
Pekin Cancer Treatment CenterPekin, Illinois  61554
Illinois Oncology Research Association CCOPPeoria, Illinois  61615
Illinois CancerCare-PeoriaPeoria, Illinois  61615
Illinois Valley HospitalPeru, Illinois  61354
Saint Margaret's HospitalSpring Valley, Illinois  61362
Carle Foundation dba Carle Cancer CenterUrbana, Illinois  61801
Carle Clinic-Urbana MainUrbana, Illinois  61801
Saint Francis Hospital and Health CentersBeech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State BoulevardFort Wayne, Indiana  46845
Saint Vincent Hospital and Health ServicesIndianapolis, Indiana  46260
Howard Regional Healthcare SystemKokomo, Indiana  46904
Saint Anthony Memorial Health CenterMichigan City, Indiana  46360
Reid Hospital and Health Care ServicesRichmond, Indiana  47374
Saint Joseph's Medical CenterSouth Bend, Indiana  46617
McFarland ClinicAmes, Iowa  50010
Constantinou, Costas L MD (UIA Investigator)Bettendorf, Iowa  52722
Cedar Rapids Oncology AssociationCedar Rapids, Iowa  52403
Mercy HospitalCedar Rapids, Iowa  52403
Medical Oncology and Hematology Associates-West Des MoinesClive, Iowa  50325
Genesis Medical Center - East CampusDavenport, Iowa  52803
Iowa Oncology Research Association CCOPDes Moines, Iowa  50309
Mercy CapitolDes Moines, Iowa  50307
Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des MoinesDes Moines, Iowa  50309
Mercy Medical Center-Sioux CitySioux City, Iowa  51104
Saint Luke's Regional Medical CenterSioux City, Iowa  51104
Siouxland Hematology - Oncology AssociatesSioux City, Iowa  51101
Covenant Medical CenterWaterloo, Iowa  50702
Cancer Center of Kansas - El DoradoEl Dorado, Kansas  67042
Cancer Center of Kansas-KingmanKingman, Kansas  67068
Radiation Oncology Practice Corporation SouthwestOverland Park, Kansas  66210
Cancer Center of Kansas - ParsonsParsons, Kansas  67357
Cancer Center of Kansas - PrattPratt, Kansas  67124
Stormont-Vail Regional Health CenterTopeka, Kansas  66604
Saint Francis Hospital and Medical Center - TopekaTopeka, Kansas  66606
Cancer Center of Kansas-Wichita Medical Arts TowerWichita, Kansas  67208
Cancer Center of Kansas - Main OfficeWichita, Kansas  67214
Associates in Oncology Hematology PC -KensingtonKensington, Maryland  20895
Associates In Oncology Hematology PC-RockvilleRockville, Maryland  20878
Berkshire Hematology Oncology PCPittsfield, Massachusetts  01201
Hickman Cancer CenterAdrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology ProgramAnn Arbor, Michigan  48106
Oakwood HospitalDearborn, Michigan  48123
Saint John Hospital and Medical CenterDetroit, Michigan  48236
Green Bay Oncology - EscanabaEscanaba, Michigan  49431
Spectrum Health-Blodgett CampusGrand Rapids, Michigan  49506
Grand Rapids Clinical Oncology ProgramGrand Rapids, Michigan  49503
Saint Mary's Health CareGrand Rapids, Michigan  49503
Spectrum Health at Butterworth CampusGrand Rapids, Michigan  49503
Green Bay Oncology - Iron MountainIron Mountain, Michigan  49801
Allegiance HealthJackson, Michigan  49201
Sparrow HospitalLansing, Michigan  48912
Saint Mary Mercy HospitalLivonia, Michigan  48154
Mercy Memorial HospitalMonroe, Michigan  48162
Mercy Health Partners-Mercy CampusMuskegon, Michigan  49443
Mercy Health Partners-Hackley CampusMuskegon, Michigan  49442
Northern Michigan Regional HospitalPetoskey, Michigan  49770
Saint Joseph Mercy OaklandPontiac, Michigan  48341-2985
Saint Joseph Mercy Port HuronPort Huron, Michigan  48060
Saint Mary's of MichiganSaginaw, Michigan  48601
Lakeland HospitalSt. Joseph, Michigan  49085
Saint John Macomb-Oakland HospitalWarren, Michigan  48093
Saint Mary's Medical CenterDuluth, Minnesota  55805
Miller-Dwan HospitalDuluth, Minnesota  55805
Duluth Clinic CCOPDuluth, Minnesota  55805
Unity HospitalFridley, Minnesota  55432
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Minnesota  55109
North Memorial Medical Health CenterRobbinsdale, Minnesota  55422
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-WoodburyWoodbury, Minnesota  55125
Southeast Missouri HospitalCape Girardeau, Missouri  63701
Radiation Oncology Practice Corporation - NorthKansas City, Missouri  64154
Saint Luke's Cancer InstituteKansas City, Missouri  64111
Radiation Oncology Practice Corporation SouthKansas City, Missouri  64114
Saint Luke's Hospital of Kansas CityKansas City, Missouri  64111
Saint Joseph Health CenterKansas City, Missouri  64114
Liberty Radiation Oncology ClinicKansas City, Missouri  64116
Truman Medical CenterKansas City, Missouri  64108
Saint Louis-Cape Girardeau CCOPSaint Louis, Missouri  63141
Missouri Baptist Medical CenterSaint Louis, Missouri  63131
Saint John's Mercy Medical CenterSaint Louis, Missouri  63141
Saint Louis Cancer and Breast InstituteSaint Louis, Missouri  63109
Ozark Health Ventures LLC dba Cancer Research for The Ozarks SpringfieldSpringfield, Missouri  65802
Saint John's HospitalSpringfield, Missouri  65804
Cox Medical CenterSpringfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PCBillings, Montana  59101
Saint Vincent HealthcareBillings, Montana  59101
Deaconess Medical CenterBillings, Montana  59107
Billings ClinicBillings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment CenterButte, Montana  59701
Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator)Great Falls, Montana  59405
Saint Peter's Community HospitalHelena, Montana  59601
Glacier Oncology PLLCKalispell, Montana  59901
Community Medical HospitalMissoula, Montana  59801
Saint Patrick Hospital - Community HospitalMissoula, Montana  59802
Lincoln Medical Education Foundation Cancer Resource CenterLincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOPOmaha, Nebraska  68106
Exeter HospitalExeter, New Hampshire  03833
Cheshire Medical Center-Dartmouth-Hitchcock KeeneKeene, New Hampshire  03431
Ocean Medical CenterBrick, New Jersey  08724
Cooper Hospital University Medical CenterCamden, New Jersey  08103
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington CountyMount Holly, New Jersey  08060
Virtua West Jersey Hospital VoorheesVoorhees, New Jersey  08043
Orange Regional Medical CenterMiddletown, New York  10940
New York University Langone Medical CenterNew York, New York  10016
Columbia University Medical CenterNew York, New York  10032
State University of New York Upstate Medical UniversitySyracuse, New York  13210
Alamance Regional Medical CenterBurlington, North Carolina  27216
Wayne Memorial HospitalGoldsboro, North Carolina  27534
Kinston Medical Specialists PAKinston, North Carolina  28501
Saint Alexius Medical CenterBismarck, North Dakota  58501
Medcenter One Health SystemsBismarck, North Dakota  58501
Aultman Health FoundationCanton, Ohio  44710
Mount Carmel Health Center WestColumbus, Ohio  43222
Good Samaritan Hospital - DaytonDayton, Ohio  45406
Dayton CCOPDayton, Ohio  45429
Samaritan North Health CenterDayton, Ohio  45415
Veteran Affairs Medical CenterDayton, Ohio  45428
Hematology Oncology Center IncorporatedElyria, Ohio  44035
Blanchard Valley HospitalFindlay, Ohio  45840
Atrium Medical Center-Middletown Regional HospitalFranklin, Ohio  45005-1066
Kettering Medical CenterKettering, Ohio  45429
Toledo Radiation Oncology at Northwest Ohio Onocolgy CenterMaumee, Ohio  43537
Bayview Oncology AssociatesOregon, Ohio  43616
Saint Charles HospitalOregon, Ohio  43616
North Coast Cancer CareSandusky, Ohio  44870
Flower Memorial HospitalSylvania, Ohio  43560
Toledo Community Hospital Oncology Program CCOPToledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy HospitalToledo, Ohio  43623
University of ToledoToledo, Ohio  43614
The Toledo HospitalToledo, Ohio  43606
Saint Vincent Mercy Medical CenterToledo, Ohio  43608
Upper Valley Medical CenterTroy, Ohio  45373
Legacy Good Samaritan Hospital and Medical CenterPortland, Oregon  97210
Northwest Cancer Specialists-Rose Quarter Cancer CenterPortland, Oregon  97227
Ephrata Cancer CenterEphrata, Pennsylvania  17522
Riddle HospitalMedia, Pennsylvania  19063
Hematology and Oncology Associates of North East PennsylvaniaScranton, Pennsylvania  18508
Scranton Hematology OncologyScranton, Pennsylvania  18510
Mercy HospitalScranton, Pennsylvania  18501
Mainline Health CCOPWynnewood, Pennsylvania  19096
AnMed Health HospitalAnderson, South Carolina  29621
Greenville CCOPGreenville, South Carolina  29615
Upstate Carolina CCOPSpartanburg, South Carolina  29303
Sanford Cancer Center-Oncology ClinicSioux Falls, South Dakota  57104
Sanford University of South Dakota Medical CenterSioux Falls, South Dakota  57117-5134
The Don and Sybil Harrington Cancer CenterAmarillo, Texas  79106
Fredericksburg Oncology IncFredericksburg, Virginia  22401
Auburn Regional Medical CenterAuburn, Washington  98002
Saint Francis HospitalFederal Way, Washington  98003
Providence - Saint Peter HospitalOlympia, Washington  98506-5166
Good Samaritan Community HospitalPuyallup, Washington  98372
Northwest CCOPTacoma, Washington  98405
Multicare Health SystemTacoma, Washington  98415
Saint Clare HospitalTacoma, Washington  98499
Saint Joseph Medical CenterTacoma, Washington  98405
Sacred Heart HospitalEau Claire, Wisconsin  54701
Saint Vincent HospitalGreen Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's HospitalGreen Bay, Wisconsin  54303
Saint Mary's HospitalGreen Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent HospitalGreen Bay, Wisconsin  54301-3526
Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311-6519
Dean Hematology and Oncology ClinicMadison, Wisconsin  53717
Bay Area Medical CenterMarinette, Wisconsin  54143
Marshfield Clinic-Minocqua CenterMinocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care IncOconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto FallsOconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer CenterRhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake CenterRice Lake, Wisconsin  54868
Saint Michael's HospitalStevens Point, Wisconsin  54481
Green Bay Oncology - Sturgeon BaySturgeon Bay, Wisconsin  54235
University of California Medical Center At Irvine-Orange CampusOrange, California  92868
Cancer Care Associates-YaleTulsa, Oklahoma  74136-1929
Cancer Care Associates-MidtownTulsa, Oklahoma  74104
Women and Infants HospitalProvidence, Rhode Island  02905
Colorado Gynecologic Oncology GroupAurora, Colorado  80010
Lake University Ireland Cancer CenterMentor, Ohio  44060
Cedar Valley Medical SpecialistsWaterloo, Iowa  50702
Jupiter Medical CenterJupiter, Florida  33458
Hubert H Humphrey Cancer CenterRobbinsdale, Minnesota  55422
University of IllinoisChicago, Illinois  60612
Stony Brook University Medical CenterStony Brook, New York  11794
John Muir Medical Center-Concord CampusConcord, California  94520
Saint Jude Medical CenterFullerton, California  92835
Christiana Healthcare Services - Christian HospitalNewark, Delaware  19718
Mount Sinai Medical Center CCOPMiami Beach, Florida  33140
The Memorial Hospital at EastonEaston, Maryland  21601
Memorial Hospital at Easton - Shore Regional Cancer CenterEaston, Maryland  21601
Commonwealth Hematology Oncology PC-WorcesterWorcester, Massachusetts  01605
University of Michigan University HospitalAnn Arbor, Michigan  48109
University of Missouri - Ellis FischelColumbia, Missouri  65203
Renown Regional Medical CenterReno, Nevada  89502
Hackensack University Medical CCOPHackensack, New Jersey  07601
UMDNJ - New Jersey Medical SchoolNewark, New Jersey  07103
Moses Cone Health System-Regional Cancer CenterGreensboro, North Carolina  27403
Annie Penn Memorial HospitalReidsville, North Carolina  27320
North Coast Cancer Care-ClydeClyde, Ohio  43410
Chestnut Hill Health SystemPhiladelphia, Pennsylvania  19118
Sandra L Maxwell Cancer CenterCedar City, Utah  84720
Intermountain Medical CenterMurray, Utah  84157
Utah Valley Regional Medical CenterProvo, Utah  84603
Dixie Medical Center Regional Cancer CenterSaint George, Utah  84770
Intermountain Health CareSalt Lake City, Utah  84103
Utah Cancer Specialists-Salt Lake CitySalt Lake City, Utah  84106
Marshfield Clinic-Chippewa CenterChippewa Falls, Wisconsin  54729
Holy Family Memorial HospitalManitowoc, Wisconsin  54221
Medical Consultants LimitedMilwaukee, Wisconsin  53215
Vince Lombardi Cancer Clinic-SheboyganSheboygan, Wisconsin  53081
Vince Lombardi Cancer Clinic - SlingerSlinger, Wisconsin  53086
Northern New Jersey CCOPHackensack, New Jersey  07601
Washington Regional Medical Center - FayettevilleFayetteville, Arkansas  72703
Highlands Oncology Group PA - FayettevilleFayetteville, Arkansas  72703
University of California at Los Angeles (UCLA )Los Angeles, California  90095
Hawaii Minority Based CCOPHonolulu, Hawaii  96813
Advocate Lutheran General HospitalPark Ridge, Illinois  60068
Maine Medical Center-Bramhall CampusPortland, Maine  04102
Gynecologic Oncology of West Michigan PLLCGrand Rapids, Michigan  49546
Center of Hope at Renown Medical CenterReno, Nevada  89502
Schwartz Gynecologic Oncology PLLCBrightwaters, New York  11718
State University of New York Downstate Medical CenterBrooklyn, New York  11203
Monter Cancer CenterLake Success, New York  11042
Hope, A Women's Cancer CenterAsheville, North Carolina  28816
Magee-Womens Hospital - University of Pittsburgh Medical CenterPittsburgh, Pennsylvania  15213
Black Hills Obstetrics and GynecologyRapid City, South Dakota  57701
Chattanooga Gynecological OncologyChattanooga, Tennessee  37403
East Tennessee State UniversityJohnson City, Tennessee  37614-0054
Texas Tech University Health Sciences CenterLubbock, Texas  79430
Bon Secours Commonwealth Gynecologic OncologyRichmond, Virginia  23226
Carilion Clinic Gynecological OncologyRoanoke, Virginia  24016
Northwest Medical Specialties PLLCTacoma, Washington  98405
Aurora Women's Pavilion of Aurora West Allis Medical CenterWest Allis, Wisconsin  53227
Long Beach Memorial Medical Center-Todd Cancer InstituteLong Beach, California  90806
Kaiser Permanente Medical Care Program - Los Angeles Medical Center & Sunset HospitalLos Angeles, California  90027
Kaiser Permanente Los Angeles Medical CenterLos Angeles, California  90027
Santa Barbara Hematology Oncology Group Inc-Santa BarbaraSanta Barbara, California  93105
Rocky Mountain Gynecologic Oncology PCEnglewood, Colorado  80110
Christiana Gynecologic Oncology LLCNewark, Delaware  19713
Saint Vincent's Medical CenterJacksonville, Florida  32204
University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, Florida  33136
Bayfront Outpatient Health ClinicSaint Petersburg, Florida  33701
Grady Health SystemAtlanta, Georgia  30303
Chicago Gynecologic Oncology SCPalatine, Illinois  60067
Norton Health Care Pavilion - DowntownLouisville, Kentucky  40202
Christus Schumpert Saint Mary's PlaceShreveport, Louisiana  71101
Kaiser Permanente - Largo Medical CenterLargo, Maryland  20774
Kaiser Permanente - Towson Medical CenterLutherville, Maryland  21093
Kaiser Permanente - Shady Grove Medical CenterRockville, Maryland  20850
University of Minnesota Medical Center-FairviewMinneapolis, Minnesota  55455
Saint Dominic-Jackson Memorial HospitalJackson, Mississippi  39216
Capital Regional Medical CenterJefferson City, Missouri  65101
Frisbie HospitalRochester, New Hampshire  03867
Southwest Gynecologic Oncology Associates IncAlbuquerque, New Mexico  87106
Saint Joseph's Hospital Health CenterSyracuse, New York  13203
FirstHealth of the Carolinas-Moore Regional HosiptalPinehurst, North Carolina  28374
Piedmont Hematology Oncology Associates PLLCWinston-Salem, North Carolina  27103
York Cancer Center-Wellspan HealthYork, Pennsylvania  17403
Knoxville Gynecologic Cancer Specialists PCKnoxville, Tennessee  37920
University of Tennesee Health Science CenterMemphis, Tennessee  38103
Kaiser Permanente - Fair Oaks Medical CenterFairfax, Virginia  22033