Inclusion Criteria:

- Diagnosis of non-small-cell carcinoma of the lung

- Patients with locally advanced disease or metastatic disease, candidates to surgery
after evaluation by oncologist and thoracic surgeon

- Tumour with possibility of curative surgery

- At least one uni-dimensionally measurable lesion

- Adequate pulmonary function to perform the planned surgical resection

Exclusion Criteria:

- Active infection (at the investigator's discretion)

- Pregnancy or breast-feeding

- Serious concomitant illness at the investigator's discretion

- Previous diagnosis of malignant disease

- They have received treatment during the last 30 days with a drug, other than the
study drug, that has not received regulatory approval for any indication at the time
of their entry in the study