Cognitive Rehabilitation of Glioma Patients: a Prospective, Randomized Study
The majority of patients with (low-grade) glioma exhibit cognitive symptoms and objective
deficits, which have a sustained, negative impact on daily functioning and quality of life.
Adult patients with a low-grade glioma, either histologically proven, or suspected (1), as
well as adult anaplastic glioma patients with favorable prognostic factors (2), who are
clinically stable for at least 6 months, will be recruited from 9 hospitals in the
Netherlands. Consenting patients with both subjective cognitive symptoms and objective
deficits will be randomized to either the cognitive rehabilitation program (N = 75) or a
"waiting-list" control group (N = 75). Upon completion of the study, those patients assigned
to the control group will be given the opportunity to undergo the cognitive rehabilitation
The cognitive rehabilitation program incorporates both retraining of impaired cognitive
functions, and teaching of compensatory strategies. Rehabilitation will be directed towards
attention, memory and executive functioning. The intervention will consist of 6 weekly,
individual, 2-hour sessions plus two hours of homework.
To evaluate the efficacy of the rehabilitation program, objective neuropsychological
functioning, self-reported cognitive symptoms and health-related quality of life will be
assessed before rehabilitation, directly following rehabilitation, and at 6-month follow-up.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
neuropsychological measures of attention (test scores)
baseline, immediately after 6 weeks and at 6-month follow-up
Martin JB Taphoorn, MD, PhD
Medical Center Haaglanden
Netherlands: Medical Ethics Review Committee (METC)