Inclusion Criteria:

Patients must be/have:

- Histological evidence of malignancy

- Advanced solid tumors that have recurred or progressed following standard therapy

- Failed one prior therapy or have no standard therapy available

- Ambulatory with ECOG of 0-1 and estimated life expectancy of > 3 months

- If female, negative pregnancy test

- If of childbearing years, agree to use birth control

- If patient with prior radiation therapy for brain metastases, on steroids, must have
been stable for 1 month

Exclusion Criteria:

Patients will be excluded if they are or have had:

- Prior radiation within 4 weeks

- Active medical condition or organ disease which may compromise safety or interfere
with the study

- Clinically significant cardiac co-morbidities or pulmonary impairment

- Concomitant therapy needs

- Treated with any investigational drugs within 30 days

- Tumors involve major artery or vein

- Prior or concurrent central nervous system (CNS) disease

- Less than 4 weeks since major surgery

- Known to be positive for HIV, hepatitis B or C

- Concurrent use of aspirin

- Use of thrombolytic agents

- Uncontrolled hypertension

- Grade II-IV peripheral vascular disease

- Pregnant or lactating

- Prior allergic history to compounds of similar chemical composition

- Inpatients

- Grade II-IV peripheral neuropathy