Trial Information

Comprehensive Screening for Women at High Genetic Risk for Developing Breast Cancer

General Purpose: The purpose of our protocol is develop a comprehensive screening protocol
for women at high risk for developing breast cancer in the hopes of detecting breast cancer
or it's precursor lesions at the earliest possible stage and reducing breast cancer
mortality.

The following are our specific goals in this endeavor;

1. To assess the sensitivity and specificity of MRI in breast cancer detection in women at
high risk compared to mammography

2. To assess the ability of random periareolar fine needle aspiration to detect abnormal
ductal cells and to correlate these results with MRI and mammogram findings

3. To assess appropriate screening intervals for BRCA1/2 mutation carriers and women with
a >10% risk of developing breast cancer in ten years The following aims will be
outlined in detail under methodology.