Combined Thoracoscopic and Laparoscopic Esophagectomy vs. Hand-assisted Transhiatal Esophagectomy: A Prospective Trial.
Open esophagectomy can be associated with significant morbidity. We hypothesize that
laparoscopic esophagectomy is associated with reduced morbidity and a faster recovery.
1. Combined thoracoscopic and laparoscopic esophagectomy can be performed safely.
2. Combined thoracoscopic and laparoscopic esophagectomy is associated with reduced
postoperative pain, decrease ICU and hospital stay, and reduced postoperative wound
3. Combined thoracoscopic and laparoscopic esophagectomy is associated with similar long
term survival as with the open approach for patients with esophageal malignancies.
OBJECTIVES AND SPECIFIC AIMS:
1. To compare short-term outcome such as operative time, operative and in-patient costs,
operative complications, length of hospital stay, and postoperative complications
between combined thoracoscopic/ laparoscopic esophagectomy and transhiatal
2. To evaluate physiologic outcomes after minimally invasive esophagectomy vs. transhiatal
3. To determine the long-term outcome, disease-free survival, survival and quality of life
after minimally invasive esophagectomy compared to transhiatal esophagectomy
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
short-term surgical outcome of minimally invasive esophagectomy vs. transhiatal esophagectomy
Ninh T Nguyen, MD
University of California, Irvine
United States: Institutional Review Board