Inclusion Criteria:

- Histologic or cytologic diagnosis of nonresectable or metastatic pancreatic
adenocarcinoma

- Chemotherapy naïve or chemotherapy experienced pancreatic cancer

Exclusion Criteria:

- Prior cancer vaccines or gene therapy

- History of clinically significant autoimmune disease (eg, systemic lupus
erythematosus, sarcoidosis, rheumatoid arthritis, glomerulonephritis, or vasculitis)

- History of another malignancy in the past five years, except adequately treated
non-melanomatous skin cancer or superficial bladder cancer or carcinoma-in-situ of
the cervix, unless approved by the Medical Monitor