The Utility of Functional and Morphologic MRI in the Detection of Prostate Cancer for Patients With Elevated PSA and Prior Negative Biopsy
Prostate specific antigen (PSA) and digital rectal exam (DRE) are used to screen for
prostate cancer. Patients with abnormal DRE or elevated PSA undergo transrectal ultrasound
guided biopsy (TRUS-Bx). There are some men who have a normal TRUS-Bx despite persistent
elevated PSA and may harbor occult prostate cancer. The purpose of this study is to
determine if MRI using an endorectal coil, and advanced MRI methods called H1 MR
Spectroscopy (MRS) and Dynamic MR Perfusion Imaging (dMRI) can help identify and localize
prostate cancer in these patients and direct repeat TRUS-Bx to the most suspicious location
in the prostate gland. 100 men, currently under observation with elevated PSA but negative
TRUS-Bx will be enrolled in the study.
Interventional
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Masoom Haider, MD
Principal Investigator
University Health Network, Toronto
Canada: Health Canada
02-0065-C
NCT00242060
November 2002
November 2008
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