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The Utility of Functional and Morphologic MRI in the Detection of Prostate Cancer for Patients With Elevated PSA and Prior Negative Biopsy


N/A
18 Years
N/A
Not Enrolling
Male
Elevated PSA, Prostate Cancer

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Trial Information

The Utility of Functional and Morphologic MRI in the Detection of Prostate Cancer for Patients With Elevated PSA and Prior Negative Biopsy


Prostate specific antigen (PSA) and digital rectal exam (DRE) are used to screen for
prostate cancer. Patients with abnormal DRE or elevated PSA undergo transrectal ultrasound
guided biopsy (TRUS-Bx). There are some men who have a normal TRUS-Bx despite persistent
elevated PSA and may harbor occult prostate cancer. The purpose of this study is to
determine if MRI using an endorectal coil, and advanced MRI methods called H1 MR
Spectroscopy (MRS) and Dynamic MR Perfusion Imaging (dMRI) can help identify and localize
prostate cancer in these patients and direct repeat TRUS-Bx to the most suspicious location
in the prostate gland. 100 men, currently under observation with elevated PSA but negative
TRUS-Bx will be enrolled in the study.


Inclusion Criteria:



- prior ultrasound biopsy of prostate showing no cancer or only single microfocus of
cancer

Exclusion Criteria:

- contraindication to contrast enhanced endorectal coil MRI

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Principal Investigator

Masoom Haider, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Health Network, Toronto

Authority:

Canada: Health Canada

Study ID:

02-0065-C

NCT ID:

NCT00242060

Start Date:

November 2002

Completion Date:

November 2008

Related Keywords:

  • Elevated PSA
  • Prostate Cancer
  • Prostatic Neoplasms

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